The new chassis in the flask: Advances in Vibrio natriegens biotechnology research.

Autor: Lima M; Department of Energy, Environmental, and Chemical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA., Muddana C; Clarity Bio Systems India Pvt. Ltd., Pune, India., Xiao Z; Department of Energy, Environmental, and Chemical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA., Bandyopadhyay A; Department of Biology, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA., Wangikar PP; Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India., Pakrasi HB; Department of Biology, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA., Tang YJ; Department of Energy, Environmental, and Chemical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA. Electronic address: yinjie.tang@wustl.edu.
Jazyk: angličtina
Zdroj: Biotechnology advances [Biotechnol Adv] 2024 Dec; Vol. 77, pp. 108464. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1016/j.biotechadv.2024.108464
Abstrakt: Biotechnology has been built on the foundation of a small handful of well characterized and well-engineered organisms. Recent years have seen a breakout performer gain attention as a new entrant into the bioengineering toolbox: Vibrio natriegens. This review covers recent research efforts into making V. natriegens a biotechnology platform, using a large language model (LLM) and knowledge graph to expedite the literature survey process. Scientists have made advancements in research pertaining to the fundamental metabolic characteristics of V. natriegens, development and characterization of synthetic biology tools, systems biology analysis and metabolic modeling, bioproduction and metabolic engineering, and microbial ecology. Each of these subcategories has relevance to the future of V. natriegens for bioengineering applications. In this review, we cover these recent advancements and offer context for the impact they may have on the field, highlighting benefits and drawbacks of using this organism. From examining the recent bioengineering research, it appears that V. natriegens is on the precipice of becoming a platform bacterium for the future of biotechnology.
Competing Interests: Declaration of competing interest None of the authors has any potential or actual conflicts of interest to disclose.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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