Biotics as novel therapeutics in targeting signs of skin ageing via the gut-skin axis.

Autor: Millman JF; Health and Happiness (H&H) Group, H&H Research, Level 6 & 7, 88 Langridge St, Collingwood, VIC 3066, Australia. Electronic address: jasmine.millman@hh.global., Kondrashina A; Health and Happiness (H&H) Group, H&H Research, National Food Innovation Hub, Teagasc Moorepark, Fermoy, Co., Cork P61K202, Ireland., Walsh C; Health and Happiness (H&H) Group, H&H Research, National Food Innovation Hub, Teagasc Moorepark, Fermoy, Co., Cork P61K202, Ireland., Busca K; Health and Happiness (H&H) Group, H&H Research, National Food Innovation Hub, Teagasc Moorepark, Fermoy, Co., Cork P61K202, Ireland., Karawugodage A; Health and Happiness (H&H) Group, H&H Research, Level 6 & 7, 88 Langridge St, Collingwood, VIC 3066, Australia., Park J; Health and Happiness (H&H) Group, H&H Research, Level 6 & 7, 88 Langridge St, Collingwood, VIC 3066, Australia., Sirisena S; Health and Happiness (H&H) Group, H&H Research, Level 6 & 7, 88 Langridge St, Collingwood, VIC 3066, Australia., Martin FP; Health and Happiness (H&H) Group, H&H Research, Avenue Sécheron 15 Bat F2/F3, Geneva 1202, Switzerland., Felice VD; Health and Happiness (H&H) Group, H&H Research, National Food Innovation Hub, Teagasc Moorepark, Fermoy, Co., Cork P61K202, Ireland., Lane JA; Health and Happiness (H&H) Group, H&H Research, National Food Innovation Hub, Teagasc Moorepark, Fermoy, Co., Cork P61K202, Ireland. Electronic address: jonathan@hh.global.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2024 Dec; Vol. 102, pp. 102518. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1016/j.arr.2024.102518
Abstrakt: Skin ageing is a phenomenon resulting from the aggregative changes to skin structure and function and is clinically manifested by physical features such as wrinkles, hyperpigmentation, elastosis, telangiectasia, and deterioration of skin barrier integrity. One of the main drivers of skin ageing, UV radiation, negatively influences the homeostasis of cells and tissues comprising the skin by triggering production of immune-mediated reactive oxygen species (ROS) and pro-inflammatory cytokines, as well as a various hormones and neuropeptides. Interestingly, an established link between the gut and the skin coined the 'gut-skin axis' has been demonstrated, with dysbiosis and gut barrier dysfunction frequently observed in certain inflammatory skin conditions and more recently, implicated in skin ageing. Therapeutic use of 'biotics' including prebiotics, probiotics, postbiotics, and synbiotics, which modulate the gut microbiota and production of microbially associated metabolites, influence the activity of the gut mucosal and immune systems and are showing promise as key candidates in addressing signs of skin ageing. In this review we aim to focus on the structure and function of the gut-skin axis and showcase the recent in-vitro and clinical evidence demonstrating the beneficial effects of select biotics in targeting signs of skin ageing and discuss the proposed mechanisms mediated via the gut-skin axis underpinning these effects.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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