CT Perfusion imaging as prognostic factor for outcome of lacunar stroke.

Autor: Mausbach S; Department of Neurology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Shmuel Bait 12, Jerusalem, 9103102, Israel. Mausbach@posteo.de.; 2Department of Neurocritical Care Medicine, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. Mausbach@posteo.de., Abdallah LA; Department of Neurology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Shmuel Bait 12, Jerusalem, 9103102, Israel., Ben-David E; Department of Radiology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Teitcher M; Department of Neurology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Shmuel Bait 12, Jerusalem, 9103102, Israel., Bornstein NM; Department of Neurology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Shmuel Bait 12, Jerusalem, 9103102, Israel., Eichel R; Department of Neurology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Shmuel Bait 12, Jerusalem, 9103102, Israel.
Jazyk: angličtina
Zdroj: Neuroradiology [Neuroradiology] 2024 Dec; Vol. 66 (12), pp. 2223-2231. Date of Electronic Publication: 2024 Oct 10.
DOI: 10.1007/s00234-024-03480-2
Abstrakt: Background: Early neurological deterioration (END) affects 20-30% of patients with lacunar stroke within 48 h despite optimal treatment. Previously established markers included infection and infarct location on imaging. We studied the utility of measuring global cerebral blood flow (gCBF) measured by CT-Perfusion (CTP) as an early predictor of END in patients with lacunar strokes.
Methods: 162 patients with lacunar stroke were measured for gCBF including both cerebral hemispheres and cerebellum. We stratified patients by normal gCBF (> 40 ml/100 mg/min) vs. low gCBF (< 40 ml/100 mg/min). Stroke location, vascular risk factors, age and gender were assessed. The primary outcome was the change in the NIHSS score after 48 h from index stroke.
Results: Mean gCBF of the overall cohort was 37.72 ml/100 mg/min. Both groups had a baseline NIHSS score of 4.2 with similar standard deviations. The NIHSS score decreased by 1.3 points in normal gCBF group and increased by 1.1 points in the low gCBF group. All stroke sites deteriorated in the low gCBF group, particularly the capsula interna, corona radiata, and lateral pontine area. END occurred in 37.8% in low gCBF compared to 3.1% in the normal gCBF patients. In contrast, clinical improvement after 48 h occurred in 64.2% of patients with normal gCBF but only 6.1% with low gCBF.
Conclusion: Our study supports measurement of gCBF by CTP as a potential imaging biomarker for END. Additionally, it adds evidence to the body of supporting the vulnerability of capsula interna and pontine infarctions to END.
Competing Interests: Declarations. Informed consent: Not applicable due to retrospective anonymous study. Ethical approval: Helsinki 0246-22-SZMC. Conflicting interests: The authors declare that there is no conflict of interest.
(© 2024. The Author(s).)
Databáze: MEDLINE
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