Cleft lip and palate and periconception COVID-19 infection in five arab countries.

Autor: Sabbagh HJ; Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, PO Box 80200, Jeddah, 21589, Saudi Arabia. hsabbagh@kau.edu.sa., Zeinalddin M; Omani Craniofacial and Cleft Society, Muscat, Oman., Al-Batayneh OB; Department of Orthodontics, Pediatric and Community Dentistry, College of Dental Medicine, University of Sharjah, PO Box 27272, Sharjah, United Arab Emirates.; Preventive Dentistry Department, Faculty of Dentistry, Jordan University of Science & Technology, Irbid, 22110, Jordan., Al Bulushi T; Plastic and Craniofacial Surgery, Khoula Hospital, Muscat, Oman., AboulHassan MA; Pediatric Plastic Surgery Department, Cairo University, Giza, Egypt., Koraitim M; Maxillofacial and Plastic Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt., Alkharafi L; Cleft and Craniofacial Unit, Ministry of Health, Kuwait, Kuwait., Almuqbali B; Ministry of Health, Khoula Hospital, Muscat, Oman., Alghamdi SM; Pediatric Dentistry Department, Bisha Dental Centre, Ministry of Health, Bisha, Saudi Arabia., Bahdila D; Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, PO Box 80200, Jeddah, 21589, Saudi Arabia., Refahee SM; Oral and Maxillofacial Surgery, Faculty of Dentistry, Fayoum University, Fayoum, Egypt., Quritum M; Department of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria University, Alexandria, Egypt., Taqi FF; Cleft and Craniofacial Unit, Ministry of Health, Kuwait, Kuwait., Albassam B; Cleft and Craniofacial Unit, Ministry of Health, Kuwait, Kuwait., Ayed M; Neonatal Department, Maternity Hospital, Kuwait, Kuwait., Embaireeg A; Neonatal Department, Maternity Hospital, Kuwait, Kuwait., Alnahdi R; Oman Dental College, Muscat, Oman., AlSharif MT; Department of Dental Public Health, Faculty of Dentistry, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Aljohar AJ; Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Abdulhameed FD; Pediatric Surgery Department, King Salman Medical City, Maternity and Children's Hospital, Madinah, Saudi Arabia., Alrejaye NS; Department of Dentistry, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia., Viswapurna PS; Oman Dental College, Muscat, Oman., Al Halasa T; Preventive Dentistry Department, Faculty of Dentistry, Jordan University of Science & Technology, Irbid, 22110, Jordan., El Tantawi M; Department of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria University, Alexandria, Egypt., Basri OA; King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia., Alamoudi RA; Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, PO Box 80200, Jeddah, 21589, Saudi Arabia.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2024 Oct 10; Vol. 28 (11), pp. 586. Date of Electronic Publication: 2024 Oct 10.
DOI: 10.1007/s00784-024-05978-8
Abstrakt: Background: Little is known about factors associated with the severity of cleft lip with or without cleft palate (CL/P) especially during the COVID-19 pandemic with its dramatic changes.
Objectives: The aim of this multi-national study is to measure the association between CL/P severity, COVID-19 infection, and fear of COVID-19 in five Arab countries.
Methods: This cross-sectional study took place in major governmental hospitals in five Arab countries from November 2020 to April 2023. Participants were infants born with CL/P and their mothers who were in their 1st trimester during the COVID-19 pandemic. Clinical examination was carried out, and CL/P cases were grouped according to phenotype: cleft lip and palate (CLP) versus cleft lip (CL), cleft extension (incomplete versus complete), and site (unilateral versus bilateral) to assess severity. Information on maternal COVID-19 infection and fear of COVID-19 were gathered.
Results: The study recruited 273 CL/P infants. Maternal COVID-19 infection during one-month pre-gestation and 1st trimester was significantly associated with higher odds of CL/P severity (AOR = 2.707; P = 0.002) than mothers without the COVID-19 infection. Using supplements during pregnancy showed a protective effect (AOR = 0.573; P = 0.065).
Conclusion: Mothers infected with COVID-19 before and during pregnancy had more than twofold higher odds of having an infant with a more severe CL/P phenotype.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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