Pediatric Clinical Influenza Disease by Type and Subtype 2015-2020: A Multicenter, Prospective Study.

Autor:	Grioni HM; Seattle Children's Research Institute, Seattle, WA., Sullivan E; Seattle Children's Research Institute, Seattle, WA., Strelitz B; Seattle Children's Research Institute, Seattle, WA., Lacombe K; Seattle Children's Research Institute, Seattle, WA., Klein EJ; Seattle Children's Research Institute, Seattle, WA., Boom JA; Texas Children's Hospital and Baylor College of Medicine, Houston, TX., Sahni LC; Texas Children's Hospital and Baylor College of Medicine, Houston, TX., Michaels MG; UPMC Children's Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, PA., Williams JV; UPMC Children's Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, PA., Halasa NB; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN., Stewart LS; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN., Staat MA; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH., Schlaudecker EP; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH., Selvarangan R; Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, Kansas City, MO., Harrison CJ; Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, Kansas City, MO., Schuster JE; Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO., Weinberg GA; Department of Pediatrics, University of Rochester Medical Center, Rochester, NY., Szilagyi PG; Department of Pediatrics, University of Rochester Medical Center, Rochester, NY., Singer MN; University of California, San Francisco Benioff Children's Hospital Oakland, Oakland, CA., Azimi PH; University of California, San Francisco Benioff Children's Hospital Oakland, Oakland, CA., Clopper BR; Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA., Moline HL; Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA., Campbell AP; Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA., Olson SM; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control of Prevention, Atlanta, GA., Englund JA; Seattle Children's Research Institute, Seattle, WA.
Jazyk:	angličtina
Zdroj:	Journal of the Pediatric Infectious Diseases Society [J Pediatric Infect Dis Soc] 2024 Oct 10. Date of Electronic Publication: 2024 Oct 10.
DOI:	10.1093/jpids/piae108
Abstrakt:	Background: Previous investigations into clinical signs and symptoms associated with influenza types and subtypes have not definitively established differences in the clinical presentation or severity of influenza disease. Methods: The study population included children 0 through 17 years old enrolled at 8 New Vaccine Surveillance Network sites between 2015 and 2020 who tested positive for influenza virus by molecular testing. Demographic and clinical data were collected for study participants via parent/guardian interview and medical chart review. Descriptive statistics were used to summarize demographic and clinical characteristics by influenza subtype. Multivariable logistic regression and Cox proportional hazard models were used to assess effects of age, sex, influenza subtype, and history of asthma on severity, including hospital admission, need for supplemental oxygen, and length of stay. Results: Retractions, cyanosis, and need for supplemental oxygen were more frequently observed among patients with influenza A(H1N1)pdm09. Headaches and sore throat were more commonly reported among patients with influenza B. Children with influenza A(H1N1)pdm09 and children with asthma had significantly increased odds of hospital admission (adjusted odds ratio (AOR): 1.39, 95% CI: 1.14-1.69 and AOR: 2.14, 95% CI: 1.72-2.67, respectively). During admission, children with influenza A(H1N1)pdm09 had significantly increased use of supplemental oxygen compared to children with A(H3N2) (AOR: 0.60, 95% CI: 0.44-0.82) or B (AOR: 0.56, 95% CI: 0.41-0.76). Conclusions: Among children presenting to the emergency department and admitted to the hospital, influenza A(H1N1)pdm09 caused more severe disease compared to influenza A(H3N2) and influenza B. Asthma also contributed to severe influenza disease regardless of subtype. (Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society 2024. This work is written by (a) US Government employee(s) and is in the public domain in the US.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu