Novel Bis-1,2,3-triazole-thiazolidinone hybrid as anticancer agents that induce apoptosis and molecular modeling study.

Autor: Bimoussa A; Laboratory of Organic Synthesis & Physico-Molecular Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, Université Cadi Ayyad, BP PO Box 2390, Marrakech, 40001, Morocco., Oubella A; Laboratory of Organic & Physical Chemistry, Applied Bioorganic Chemistry Team, Faculty of Sciences, Ibnou Zohr University, Agadir, Morocco., Alossaimi MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia., Aziz M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, 63100, Pakistan., Attaullah HM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, 63100, Pakistan., Ejaz SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, 63100, Pakistan., Morjani H; BioSpectroscopie Translationnelle, BioSpecT-EA7506, UFR de Pharmacie, Université de Reims Champagne-Ardenne, 51 Rue Cognacq Jay, 51096, Reims Cedex, France., Auhmani A; Laboratory of Organic Synthesis & Physico-Molecular Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, Université Cadi Ayyad, BP PO Box 2390, Marrakech, 40001, Morocco., Robert A; Equipe MSO, CNRS UMR 7312 Institut de Chimie Moléculaire Université de Reims Champagne-Ardenne, Bat. Europol'Agro - Moulin de La Housse UFR SciencesB.P.,1039, 51687, Reims Cedex 2, France., Riahi A; Equipe MSO, CNRS UMR 7312 Institut de Chimie Moléculaire Université de Reims Champagne-Ardenne, Bat. Europol'Agro - Moulin de La Housse UFR SciencesB.P.,1039, 51687, Reims Cedex 2, France., Riadi Y; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia., Ait Itto MY; Laboratory of Organic Synthesis & Physico-Molecular Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, Université Cadi Ayyad, BP PO Box 2390, Marrakech, 40001, Morocco.
Jazyk: angličtina
Zdroj: Future medicinal chemistry [Future Med Chem] 2024 Oct 10, pp. 1-18. Date of Electronic Publication: 2024 Oct 10.
DOI: 10.1080/17568919.2024.2394019
Abstrakt: Aim: A series of (R)-Carvone-based 1,2,3-triazole-thiazolidinone 17a-h hybrids were synthesized and characterized by spectroscopic techniques NMR and HRMS. The chemical reactivity and the stability parameters were observed via DFT. Method/results: The objective was to evaluate the anticancer activity of the synthesized compounds against cancer cell lines. The mechanism of action by which the 17b and 17g exert their effect suggested that they may induce apoptosis through activation of caspase-3/7. This effect was observed against the most important NIMA-related kinases via Docking investigation. The designed compounds were identified as the best inhibitors of the NEK family via the inactivation of the caspase-3. The Docking results were supported by Dynamics where the binding energies justified the medicinal importance of the synthesized derivatives.
Databáze: MEDLINE