Network Analyses Applied to the Dimensions of Cancer-Related Fatigue in Women With Breast Cancer.

Autor: Baussard L; Epsylon Laboratory, University Paul Valéry Montpellier 3, Nîmes, France., Ernst M; Biostatistics and Research Methods Centre, University Hospital and University of Liège, Liège, Belgium., Diep A; Biostatistics and Research Methods Centre, University Hospital and University of Liège, Liège, Belgium., Jerusalem G; Medical Oncology Department, University Hospital and University of Liège, Liège, Belgium., Vanhaudenhuyse A; Interdisciplinary Algology Centre, University Hospital of Liège, Liège, Belgium.; Sensation and Perception Research Group, GIGA-Consciousness, University of Liège, Liège, Belgium., Marie N; Sensation and Perception Research Group, GIGA-Consciousness, University of Liège, Liège, Belgium., Bragard I; Research and Continuing Education Department, CRIG Research Center, Haute Ecole Libre Mosane (HELMo), Liège, Belgium., Faymonville ME; Sensation and Perception Research Group, GIGA-Consciousness, University of Liège, Liège, Belgium.; Arsène Burny Cancerology Institute, University Hospital of Liège, Liège, Belgium., Gosseries O; Sensation and Perception Research Group, GIGA-Consciousness, University of Liège, Liège, Belgium.; Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.; Centre du Cerveau², University Hospital of Liège, Liège, Belgium., Grégoire C; Sensation and Perception Research Group, GIGA-Consciousness, University of Liège, Liège, Belgium.
Jazyk: angličtina
Zdroj: Cancer medicine [Cancer Med] 2024 Oct; Vol. 13 (19), pp. e70268.
DOI: 10.1002/cam4.70268
Abstrakt: Background: Understanding cancer symptom cluster through network analyses is a new approach in oncology, revealing interconnected and influential relationships among reported symptoms. We aimed to assess these relationships using network analysis in posttreatment breast cancer patients, focusing on the five dimensions of cancer-related fatigue (CRF), and on other common difficulties encountered by oncological patients (i.e., pain, anxiety, depression, sleep difficulties, cognitive impairments, and emotion regulation and mental adaptation difficulties).
Method: This study involved a complementary analysis of data from two interventional studies. Participants completed questionnaires before and after the intervention, with baseline scores being used in this article. Partial correlation network analysis modeled the relationships between symptoms in five distinct networks, each of them including one specific dimension of CRF. The core symptom in each network was identified based on the highest centrality indices.
Results: Depression emerged as the core symptom in all networks, strongly associated with all fatigue dimensions (partial correlations ranging from 0.183 to 0.269) except mental fatigue. These findings indicate robust connections between symptoms, as variations in depression scores directly or indirectly influence fatigue and other symptoms within the cluster.
Conclusion: Our results support the multidimensional aspect of CRF, and its links with other common symptoms. To effectively reduce patient CRF, interventions should address not only fatigue but also the closely related symptoms from the cluster, such as depression, given its centrality in the cluster.
Trial Registration: ClinicalTrials.gov (NCT03144154 and NCT04873661). Retrospectively registered on May 1, 2017 and April 29, 2021, respectively.
(© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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