Financial toxicity in early-phase cancer clinical trial participants.

Autor: Durbin SM; Department of Medicine, Division of Hematology & Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts, USA., Lundquist D; Cancer Center Protocol Office, Massachusetts General Hospital, Boston, Massachusetts, USA., Pelletier A; Biostatistician, Brigham and Women's Hospital, Boston, Massachusetts, USA., Petrillo LA; Division of Palliative Care and Geriatric Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Bame V; Cancer Center Protocol Office, Massachusetts General Hospital, Boston, Massachusetts, USA., Turbini V; Cancer Center Protocol Office, Massachusetts General Hospital, Boston, Massachusetts, USA., Heldreth H; Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Lynch K; Cancer Center Protocol Office, Massachusetts General Hospital, Boston, Massachusetts, USA., Boulanger M; Department of Medicine, Division of Hematology & Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts, USA., Lam A; University of Oklahoma Stephenson Cancer Center, Oklahoma City, Oklahoma, USA., McIntyre C; Department of Nursing & Patient Care Services, Massachusetts General Hospital, Boston, Massachusetts, USA., Ferrell BR; City of Hope Comprehensive Cancer Center, Duarte, California, USA., Jimenez R; Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Juric D; Department of Medicine, Division of Hematology & Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts, USA., Nipp RD; University of Oklahoma Stephenson Cancer Center, Oklahoma City, Oklahoma, USA.
Jazyk: angličtina
Zdroj: Cancer [Cancer] 2024 Oct 10. Date of Electronic Publication: 2024 Oct 10.
DOI: 10.1002/cncr.35586
Abstrakt: Background: Little is known about financial toxicity in early-phase clinical trial (EP-CT) participants. This study sought to describe financial toxicity in EP-CT participants and assess associations with patient characteristics and patient-reported outcomes (PROs).
Methods: Prospectively enrolled EP-CT participants from were followed from April 2021 through January 2023. Participants completed the Comprehensive Score for Financial Toxicity (<26 = financial toxicity) at time of treatment. Quality of life (QOL), symptoms, coping, and resource concerns were surveyed. Associations of financial toxicity with patient characteristics, PROs, and clinical outcomes were explored.
Results: Of 261 eligible patients, 197 completed baseline assessments (75.5%, median age = 63.4 years [31.8-88.6], 57.4% female). Most common cancers were gastrointestinal (33.0%) and breast (20.8%). More than one third (34.0%) of patients reported financial toxicity. Patients with financial toxicity were more likely to be <65 years (70.2% vs 48.5%, p = .004), unemployed (45.5% vs 16.9%, p < .001), not have attended college (53.1% vs 26.4%, p = .002), and have income <$60,000 (59.7% vs 25.4%, p < .001). In adjusted models, patients with financial toxicity reported lower QOL (B = -6.66, p = .004) and acceptance (B = -0.78, p = .002), and increased self-blame (B = 0.87, p < .001). They were more likely to have concerns regarding housing (10.6% vs 2.3%, p = .025), bills (31.8% vs 3.8%, p < .001), food (9.1% vs 0.8%, p = .006), and employment (21.2% vs 1.5%, p < .001). There was no difference in time on trial (hazard ratio, 1.03; p = .860) or survival (hazard ratio, 1.16; p = .496).
Conclusions: More than one third of EP-CT participants reported financial toxicity. Factors associated with financial toxicity and demonstrated novel associations among financial toxicity with QOL, coping, and resource concerns were identified, highlighting the need to address financial toxicity among this population.
(© 2024 American Cancer Society.)
Databáze: MEDLINE
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