Prevalence of chronic postsurgical hypoparathyroidism not adequately controlled: an analysis of a nationwide cohort of 337 patients.

Autor:	Díez JJ; Department of Endocrinology, Hospital Universitario Puerta de Hierro Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro Segovia de Arana, Majadahonda, Spain.; Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Anda E; Department of Endocrinology, Hospital Universitario de Navarra, Pamplona, Spain., Pérez-Corral B; Department of Endocrinology, Complejo Asistencial Universitario de León, León, Spain., Paja M; Department of Endocrinology, Hospital Universitario de Basurto, Universidad del País Vasco, Universidad del País Vasco (UPV)/EHU, Bilbao, Spain., Alcazar V; Department of Endocrinology, Hospital Severo Ochoa, Leganés, Spain., Sánchez-Ragnarsson C; Department of Endocrinology, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain., Orois A; Department of Endocrinology and Nutrition, Hospital Clínic, Barcelona, Spain., Romero-Lluch AR; Department of Endocrinology, Hospital Universitario Virgen del Rocío, Sevilla, Spain., Sambo M; Department of Endocrinology, Hospital General Universitario Gregorio Marañón, Madrid, Spain., Oleaga A; Department of Endocrinology, Hospital Universitario de Basurto, Universidad del País Vasco, Universidad del País Vasco (UPV)/EHU, Bilbao, Spain., Caballero Á; Department of Endocrinology, Hospital Universitario de Canarias, Tenerife, Spain., Alhambra MR; Department of Endocrinology, Hospital Universitario Reina Sofía, Córdoba, Spain., Urquijo V; Department of Endocrinology, Hospital Universitario de Cruces, Bilbao, Spain., Delgado-Lucio AM; Department of Endocrinology, Hospital Universitario de Burgos, Burgos, Spain., Fernández-García JC; Department of Endocrinology, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga, Universidad de Málaga, Málaga, Spain., Doulatram-Gamgaram VK; Department of Endocrinology, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga, Universidad de Málaga, Málaga, Spain., Dueñas-Disotuar S; Department of Endocrinology, Hospital Universitario Virgen del Rocío, Sevilla, Spain., Martín T; Department of Endocrinology, Hospital Universitario Virgen Macarena, Sevilla, Spain., Peinado M; Department of Endocrinology, Hospital Universitario Virgen Macarena, Sevilla, Spain., Sastre J; Department of Endocrinology, Hospital Universitario de Toledo, Toledo, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Sep 25; Vol. 15, pp. 1464515. Date of Electronic Publication: 2024 Sep 25 (Print Publication: 2024).
DOI:	10.3389/fendo.2024.1464515
Abstrakt:	Purpose: The identification of patients with chronic hypoparathyroidism who are adequately (AC) or not adequately controlled (NAC) has clinical interest, since poor disease control is related to complications and mortality. We aimed to assess the prevalence of NAC patients in a cohort of subjects with postsurgical hypoparathyroidism. Methods: We performed a multicenter, retrospective, cohort study including patients from 16 Spanish hospitals with chronic hypoparathyroidism lasting ≥3 years. We analyzed disease control including biochemical profile and clinical wellness. For biochemical assessment we considered three criteria: criterion 1, normal serum calcium, phosphorus and calcium x phosphorus product; criterion 2, the above plus estimated glomerular filtration rate ≥60 ml/min/1.73 m 2 ; and criterion 3, the above plus normal 24-hour urinary calcium excretion. A patient was considered AC if he or she met the biochemical criteria and was clinically well. Results: We included 337 patients with postsurgical hypoparathyroidism (84.3% women, median age 45[36-56] years, median time of follow-up 8.9[6.0-13.0] years). The proportions of NAC patients with criteria 1, 2 and 3 were, respectively, 45.9%, 49.2% and 63.1%. Patients who had dyslipidemia at the time of diagnosis presented a significantly higher risk of NAC disease (criterion 3; OR 7.05[1.44-34.45]; P=0.016). NAC patients (criterion 2) had a higher proportion of subjects with incident chronic kidney disease and eye disorders, and NAC patients (criterion 3) had a higher proportion of incident chronic kidney disease, nephrolithiasis and dyslipidemia than AC patients. Conclusion: The present study shows a strikingly high prevalence of NAC patients in the clinical practice of Spanish endocrinologists. Results suggest that NAC disease might be associated with some prevalent and incident comorbidities. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Díez, Anda, Pérez-Corral, Paja, Alcazar, Sánchez-Ragnarsson, Orois, Romero-Lluch, Sambo, Oleaga, Caballero, Alhambra, Urquijo, Delgado-Lucio, Fernández-García, Doulatram-Gamgaram, Dueñas-Disotuar, Martín, Peinado and Sastre.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu