| Autor: |
Jang H; Buck Institute for Research on Aging, Novato, CA 94945, USA., Sharma AB; Department of Physiology; University of California San Francisco, San Francisco, CA 94158, USA., Dan U; Department of Physiology; University of California San Francisco, San Francisco, CA 94158, USA., Wong JH; Department of Physiology; University of California San Francisco, San Francisco, CA 94158, USA., Knight ZA; Department of Physiology; University of California San Francisco, San Francisco, CA 94158, USA.; Kavli Institute for Fundamental Neuroscience; University of California San Francisco, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute; University of California San Francisco, San Francisco, CA 94158, USA., Garrison JL; Buck Institute for Research on Aging, Novato, CA 94945, USA.; Center for Healthy Aging in Women, Novato, CA 94945, USA.; Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.; Leonard Davis School of Gerontology, University of Southern California; Los Angeles, CA 90089, USA. |
| Abstrakt: |
Chronic dehydration is a leading cause of morbidity for the elderly, but how aging alters the fluid homeostasis system is not well understood. Here, we used a combination of physiologic, behavioral and circuit analyses to characterize how fluid balance is affected by aging in mice. We found that old mice have a primary defect in sensing and producing the anti-diuretic hormone vasopressin, which results in chronic dehydration. Recordings and manipulations of the thirst circuitry revealed that old mice retain the ability to sense systemic cues of dehydration but are impaired in detecting presystemic, likely oropharyngeal, cues generated during eating and drinking, resulting in disorganized drinking behavior on short timescales. Surprisingly, old mice had increased drinking and motivation after 24-hour water deprivation, indicating that aging does not result in a general impairment in the thirst circuit. These findings reveal how a homeostatic system undergoes coordinated changes during aging. |
