Adrenergic signaling gates astrocyte responsiveness to neurotransmitters and control of neuronal activity.
| Autor: | Guttenplan KA; Vollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA., Maxwell I; Vollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA., Santos E; Vollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA., Borchardt LA; Vollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA., Manzo E; Vollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA., Abalde-Atristain L; Vollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA., Kim RD; Neuroscience Institute, NYU Grossman School of Medicine; New York, NY., USA., Freeman MR; Vollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA. |
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| Jazyk: | angličtina |
| Zdroj: | BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 23. Date of Electronic Publication: 2024 Sep 23. |
| DOI: | 10.1101/2024.09.23.614537 |
| Abstrakt: | How astrocytes regulate neuronal circuits is a fundamental, unsolved question in neurobiology. Nevertheless, few studies have explored the rules that govern when astrocytes respond to different neurotransmitters in vivo and how they affect downstream circuit modulation. Here, we report an unexpected mechanism in Drosophila by which G-protein coupled adrenergic signaling in astrocytes can control, or "gate," their ability to respond to other neurotransmitters. Further, we show that manipulating this pathway potently regulates neuronal circuit activity and animal behavior. Finally, we demonstrate that this gating mechanism is conserved in mammalian astrocytes, arguing it is an ancient feature of astrocyte circuit function. Our work establishes a new mechanism by which astrocytes dynamically respond to and modulate neuronal activity in different brain regions and in different behavioral states. Competing Interests: Competing interests: Authors declare that they have no competing interests. |
| Databáze: | MEDLINE |
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