Cesarian sections in women with multiple sclerosis: A Canadian prospective pregnancy study.

Autor:	Sadovnick D; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.; Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada., Criscuoli M; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.; Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada., Yee I; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.; Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada., Carruthers R; Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada., Devonshire V; Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada., Smyth P; Department of Medicine (Neurology), University of Alberta, Edmonton, Canada., Krysko KM; BARLO MS Centre, Division of Neurology, Department of Medicine, St Michael's Hospital, University of Toronto, and Li Ka Shing Knowledge Institute, Toronto, Canada.
Jazyk:	angličtina
Zdroj:	Multiple sclerosis journal - experimental, translational and clinical [Mult Scler J Exp Transl Clin] 2024 Oct 08; Vol. 10 (4), pp. 20552173241285546. Date of Electronic Publication: 2024 Oct 08 (Print Publication: 2024).
DOI:	10.1177/20552173241285546
Abstrakt:	Background: An increasing number of women with multiple sclerosis (wMS) are considering pregnancy. Prior studies suggest increased rate of elective cesarian sections (C-sections) in wMS. Methods: The Canadian Multiple Sclerosis Pregnancy Study (CANPREG-MS) is a prospective study on pregnant wMS. This report shows comparisons between (i) CANPREG-MS wMS delivered by C-section and the general population and (ii) C-section and vaginal deliveries in this study cohort. Results: CANPREG-MS has resulted in 170 deliveries with 63 by C-section. The proportion with C-sections in CANPREG-MS (37.1%) was significantly higher than that for the Canadian population (28%) ( p  = .0085). The majority (66.7%) of C-sections were not planned, and typically were performed for obstetrical indications. C-sections were performed at an earlier gestational age than vaginal deliveries, although birthweight did not differ by mode of delivery in wMS. MS relapses (3.2%) and pseudo-relapses (3.2%) were rare in the first month after C-section deliveries, regardless of disease modifying therapy decisions during gestation and postpartum. Conclusions: C-sections were more common in wMS than the general population, but few were because of maternal MS. CANPREG-MS provides informative data for pregnancies in wMS with well-managed and relatively mild disease. This information is helpful to obstetrical and MS healthcare providers. (© The Author(s), 2024.)
Databáze:	MEDLINE
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