Sex Differences in Neuropsychiatric Symptoms in Alpha-Synucleinopathies: A Systematic Review and Meta-Analysis.

Autor: Couture V; Department of Psychiatry, Division of Geriatric Psychiatry, Institut Universitaire en Santé Mentale de Montréal, Montréal, QC, Canada., Carmel JF; Division of Geriatric Psychiatry, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada., Rousseau K; Department of Psychiatry, Division of Geriatric Psychiatry, Institut Universitaire en Santé Mentale de Montréal, Montréal, QC, Canada., Létourneau G; Department of Psychiatry, Division of Geriatric Psychiatry, Institut Universitaire en Santé Mentale de Montréal, Montréal, QC, Canada., Clerc D; Division of Geriatric Psychiatry, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada., Huot P; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Neurodegenerative Disease Group, Montreal Neurological Institute Hospital, Montréal, QC, Canada., Forget MF; Department of Medicine, Division of Geriatrics, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada., Nguyen QD; Department of Medicine, Division of Geriatrics, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.; Innovation Hub, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada., Camicioli R; Department of Medicine and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada., Desmarais P; Department of Medicine, Division of Geriatrics, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.; Innovation Hub, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.
Jazyk: angličtina
Zdroj: Movement disorders clinical practice [Mov Disord Clin Pract] 2024 Nov; Vol. 11 (11), pp. 1335-1344. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1002/mdc3.14227
Abstrakt: Background: Alpha-synucleinopathies, such as Parkinson's disease (PD), Parkinson's disease dementia (PDD), and dementia with Lewy bodies (DLB), demonstrate sex differences with regard to prevalence, age of onset, and motor manifestations. Neuropsychiatric symptoms (NPS) are common early and late manifestations of these disorders.
Objectives: We aimed to describe sex differences in NPS across alpha-synucleinopathies.
Methods: We searched Web of Science Core collection databases to identify observational studies published between January 1, 2000, and June 1, 2022, reporting the prevalence or severity of NPS among individuals with a diagnosis of PD, PDD, or DLB. Prevalence and severity were pooled for each NPS according to sex using random-effects models.
Results: Two-hundred-and-forty studies, representing 796,026 participants (45% females), were included in the meta-analysis. Female sex was associated with a higher prevalence of anxiety (OR = 1.60 [95% CI: 1.40, 1.82]), depression (OR = 1.56 [1.45, 1.67]), fatigue (OR = 1.21 [1.02, 1.43]), and psychotic symptoms (OR = 1.26 [1.14, 1.40]) and more severe anxiety (g = 1.35 [95% CI: 0.58, 2.13]), depression (g = 1.57 [1.05, 2.08]), and fatigue (g = 0.86 [0.41, 1.32]), while male sex was associated with a higher prevalence of apathy (OR = 0.77 [0.63, 0.93]), impulse control disorders (OR = 0.67 [0.55, 0.82]), REM sleep behavior disorder (OR = 0.54 [0.42, 0.70]), hypersomnolence (OR = 0.67 [0.56, 0.80]), and suicide (OR = 0.30 [0.20, 0.44]).
Conclusions: NPS have different prevalences and severities in alpha-synucleinopathies according to sex. These findings support consideration of sex in the elaboration of clinical tools.
(© 2024 The Author(s). Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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