Copper-amino acid/Carboxymethyl starch composite for controllable releasing of povidone-iodine.

Autor: Morad M; Department of Chemistry, Faculty of Sciences, Umm Al-Qura University, Makkah, Saudi Arabia., Alzahrani SO; Department of Chemistry, College of Science, Taibah University, P. O. Box 344, Madinah, Saudi Arabia., Almahri A; Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia., Alatawi ISS; Department of Chemistry, College of Science, University of Tabuk, Tabuk, 71474, Saudi Arabia., Alrashdi KS; Department of Chemistry, Al-Qunfudah University College, Umm Al-Qura University, Al-Qunfudah, 1109, Saudi Arabia., Alkhamis KM; Department of Chemistry, College of Science, University of Tabuk, Tabuk, 71474, Saudi Arabia., Alsharief HH; Department of Chemistry, Faculty of Sciences, Umm Al-Qura University, Makkah, Saudi Arabia., El-Metwaly NM; Department of Chemistry, Faculty of Sciences, Umm Al-Qura University, Makkah, Saudi Arabia. n_elmetwaly00@yahoo.com.; Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street 35516, Mansoura, Egypt. n_elmetwaly00@yahoo.com.
Jazyk: angličtina
Zdroj: BMC chemistry [BMC Chem] 2024 Oct 09; Vol. 18 (1), pp. 194. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1186/s13065-024-01290-4
Abstrakt: Povidone-iodine is identified as one of the widely applicable antiseptic reagents for treatment of skin infection and wound healing. Controllable releasing of povidone-iodine is extensively required for healing of chronic wounds. The release of povidone-iodine was systematically studied from the composites based on carboxymethyl starch (CMS). Currently, different ratios from copper precursor and L-aspartic acid (L-AA) were interacted with CMS to obtain Cu-L-AA@CMS composites. Increment the percentage of L-AA was reflected in clustering of dense masses from the desirable composite with highly crystalline/stable structural network. Regardless to pH conditions, Cu-L-AA(30%)@CMS composite showed the highest efficiency for controllable release of povidone-iodine, whereas, the release percentages were estimated to be 58%, 32% and 18% at pH 5, 7 and 9, respectively. The kinetic results revealed the impossibility of povidone-iodine releasing via diffusion/erosion for further support of the hypothesis of releasing via swelling process. Moreover, the release of povidone-iodine using column technique showed that the lowest release was estimated at using high rate of 6 mL/min. Besides the biocompatibility and biodegradability of the prepared Cu-L-AA@CMS composites, it showed the superiority for controllable release of povidone-iodine antiseptic reagent to regulate its beneficial effect in curing of the skin.
(© 2024. The Author(s).)
Databáze: MEDLINE
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