High-risk pediatric medications: A listing proposal by interdisciplinary consensus technique.

Autor:	Hernández Gago Y; Servicio de Farmacia, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, España. Electronic address: yhergag@gobiernodecanarias.org., Alcalá Minagorre PJ; Servicio de Pediatría, Hospital General Universitario Dr Balmis, Alicante, España., Rodríguez Marrodán B; Servicio de Farmacia, Hospital Universitario Puerta de Hierro, Madrid, España., Hernández Sabater L; Servicio de Pediatría, Hospital General Universitario Dr Balmis, Alicante, España., Cabañas Poy MJ; Servicio de Farmacia, Hospital Universitario Vall d'Hebron, Barcelona, España., Martínez Roca C; Servicio de Farmacia, Complejo Hospitalario Universitario de A Coruña, Coruña, España., Pérez Moreno J; Servicio de Pediatría, Hospital General Universitario Gregorio Marañón, Madrid, España.
Jazyk:	English; Spanish; Castilian
Zdroj:	Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria [Farm Hosp] 2024 Oct 08. Date of Electronic Publication: 2024 Oct 08.
DOI:	10.1016/j.farma.2024.09.002
Abstrakt:	Introduction: Pediatric patients are more likely to experience medication-related errors and serious associated harms. The identification of high-risk medications (HRM) and their study in special populations, such as children with excess body weight, is a part of safety improvement strategies. Objective: To generate, through a consensus technique structured by an interdisciplinary group of pediatricians and hospital pharmacists, an operational and updated list of HRM for hospital use in children over 2 years of age. The document was part of a collaboration project between the Spanish Society of Hospital Pharmacists and the Spanish Society of Pediatric Hospital Medicine. Methods: The study was carried out in two sequential phases: a) preparation of a preliminary list of HRM through bibliographic review and b) subsequent application of the double-round Delphi method to agree on a definitive list of HRM. The results obtained were validated by calculating the probability of chance agreement and the modified Kappa statistic for each drug. Results: The original list obtained by bibliographic review included 26 pharmacological classes and 96 drugs. Of the total of 37 experts, 32 (86.4%) completed both rounds of the Delphi. The final consensus list of HRM incorporated 24 pharmacological classes and 100 drugs. The modified Kappa statistic reflected a high percent agreement (94.9%) in the consensus reached by the participants. Conclusion: This list can establish a tool for future studies and interventions to improve the safety of medications in general pediatric population, as well as in high-risk subgroups, such as pediatric patients with excess body weight. (Copyright © 2024. Publicado por Elsevier España, S.L.U.)
Databáze:	MEDLINE
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