Camptothecin and its derivatives: Advancements, mechanisms and clinical potential in cancer therapy.

Autor: Kamle M; Applied Microbiology Laboratory, Department of Forestry, North Eastern Regional Institute of Science and Technology, Nirjuli, India., Pandhi S; Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, India., Mishra S; Faculty of Agricultural Sciences, GLA University, Mathura, 281406, India., Barua S; Indian Institute of Technology Kharagpur, Kharagpur, 721302, India., Kurian A; Department of Post Graduate Studies and Research in Food Science, St. Aloysius College (Autonomous), Mangalore, 575003, India., Mahato DK; CASS Food Research Centre, School of Exercise and Nutrition Sciences, Deakin University, Burwood, VIC, 3125, Australia., Rasane P; Department of Food Technology and Nutrition, School of Agriculture, Lovely Professional University, Phagwara, 144411, India., Büsselberg D; Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha, Qatar., Kumar P; Department of Botany, University of Lucknow, Uttar Pradesh, Lucknow, India. pkbiotech@gmail.com.; College of Life Science & Biotechnology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. pkbiotech@gmail.com., Calina D; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania. calinadaniela@gmail.com., Sharifi-Rad J; Universidad Espíritu Santo, Samborondón, 092301, Ecuador. javad.sharifirad@gmail.com.; Department of Medicine, College of Medicine, Korea University, Seoul, 02841, Republic of Korea. javad.sharifirad@gmail.com.
Jazyk: angličtina
Zdroj: Medical oncology (Northwood, London, England) [Med Oncol] 2024 Oct 09; Vol. 41 (11), pp. 263. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1007/s12032-024-02527-x
Abstrakt: Camptothecin (CPT), an alkaloid isolated from the Camptotheca tree, has demonstrated significant anticancer properties in a range of malignancies. However, its therapeutic efficacy is limited by its hydrophobicity, poor bioavailability, and systemic toxicity. Derivatives, analogues, and nanoformulations of CPT have been synthesized to overcome these limitations. The aim of this review is to comprehensively analyze existing studies to evaluate the therapeutic efficacy, mechanistic aspects, and clinical potential of CPT and its modified forms, including derivatives, analogues, and nanoformulations, in cancer treatment. A comprehensive literature review was performed using PubMed/Medline, Scopus, and Web of Science databases; articles were selected based on specific inclusion criteria, and data were extracted on the pharmacological profile, clinical studies, and therapeutic efficacy of CPT and its different forms. Current evidence suggests that derivatives and analogues of CPT have improved water solubility, bioavailability, and reduced systemic toxicity compared to CPT. Nanoformulations further enhance targeted delivery and reduce off-target effects. Clinical trials indicate promising outcomes with enhanced survival rates and lower side effects. CPT and its modified forms hold significant promise as potent anticancer agents. Ongoing research and clinical trials are essential for establishing their long-term efficacy and safety; the evidence overwhelmingly supports further development and clinical testing of these compounds.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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