A review of therapies for hyperpigmentation modulating the synthesis of eumelanin to pheomelanin.

Autor: Singh IK; Michigan State University College of Osteopathic Medicine, East Lansing, MI, USA., Espinosa ML; Division of Photobiology and Photomedicine, Department of Dermatology, Henry Ford Health, 3031 W Grand Blvd, Suite 800 Dermatology, Detroit, MI, 48202, USA., Lim HW; Division of Photobiology and Photomedicine, Department of Dermatology, Henry Ford Health, 3031 W Grand Blvd, Suite 800 Dermatology, Detroit, MI, 48202, USA., Mohammad TF; Division of Photobiology and Photomedicine, Department of Dermatology, Henry Ford Health, 3031 W Grand Blvd, Suite 800 Dermatology, Detroit, MI, 48202, USA. tmohamm2@hfhs.org.
Jazyk: angličtina
Zdroj: Archives of dermatological research [Arch Dermatol Res] 2024 Oct 09; Vol. 316 (9), pp. 668. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1007/s00403-024-03411-4
Abstrakt: There are significant psychosocial burdens in patients with hyperpigmentation, which emphasizes the importance of treatment. Current gold standard for treatment is hydroquinone; however, alternatives have been developed given the concern for side effects of hydroquinone. Melanogenesis is responsible for the production of eumelanin and pheomelanin; there are many factors that will determine whether eumelanin or pheomelanin will be produced. Eumelanin is known for its photoprotective qualities, while pheomelanin is implicated in photocarcinogenesis and photoaging. Multiple treatment modalities for hyperpigmentation that shift eumelanin to pheomelanin synthesis exist. Cysteamine, glutathione, kojic acid, and methyl sulfonyl methane are four agents used to treat hyperpigmentation by shifting the production of eumelanin to pheomelanin. It is critical to discuss photoprotection with patients to help reduce the potential impact of increased pheomelanin production and to expand research in this area.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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