Effect of Tele-ICU on Clinical Outcomes of Critically Ill Patients: The TELESCOPE Randomized Clinical Trial.

Autor:	Pereira AJ; Hospital Israelita Albert Einstein, São Paulo, Brazil.; Brazilian Research in Intensive Care Network (BRICNet), São Paulo, Brazil., Noritomi DT; Hospital Israelita Albert Einstein, São Paulo, Brazil., Dos Santos MC; Hospital Israelita Albert Einstein, São Paulo, Brazil., Corrêa TD; Hospital Israelita Albert Einstein, São Paulo, Brazil.; Brazilian Research in Intensive Care Network (BRICNet), São Paulo, Brazil., Ferraz LJR; Hospital Israelita Albert Einstein, São Paulo, Brazil., Schettino GPP; Hospital Israelita Albert Einstein, São Paulo, Brazil., Cordioli E; Hospital Israelita Albert Einstein, São Paulo, Brazil., Morbeck RA; Hospital Israelita Albert Einstein, São Paulo, Brazil., Morais LC; Hospital Israelita Albert Einstein, São Paulo, Brazil., Salluh JIF; Brazilian Research in Intensive Care Network (BRICNet), São Paulo, Brazil.; D'Or Institute for Research and Education, Rio de Janeiro, Brazil., Azevedo LCP; Hospital Israelita Albert Einstein, São Paulo, Brazil.; Brazilian Research in Intensive Care Network (BRICNet), São Paulo, Brazil., Biondi RS; Brazilian Research in Intensive Care Network (BRICNet), São Paulo, Brazil.; Hospital Brasília - Dasa, Brasília, Brazil., Rosa RG; Brazilian Research in Intensive Care Network (BRICNet), São Paulo, Brazil.; Hospital Moinhos de Vento, Porto Alegre, Brazil., Cavalcanti AB; Brazilian Research in Intensive Care Network (BRICNet), São Paulo, Brazil.; HCor Research Institute, São Paulo, Brazil., Berwanger O; Hospital Israelita Albert Einstein, São Paulo, Brazil.; The George Institute for Global Health, London, United Kingdom.; Imperial College London, London, United Kingdom., Serpa Neto A; Hospital Israelita Albert Einstein, São Paulo, Brazil.; Brazilian Research in Intensive Care Network (BRICNet), São Paulo, Brazil.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.; Austin Hospital, Heidelberg, Australia., Ranzani OT; Brazilian Research in Intensive Care Network (BRICNet), São Paulo, Brazil.; Barcelona Institute for Global Health (ISGlobal), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.; Heart Institute, Hospital das Clínicas FMUSP, University of São Paulo, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	JAMA [JAMA] 2024 Dec 03; Vol. 332 (21), pp. 1798-1807.
DOI:	10.1001/jama.2024.20651
Abstrakt:	Importance: Despite its implementation in several countries, there has not been a randomized clinical trial to assess whether telemedicine in intensive care units (ICUs) could improve clinical outcomes of critically ill patients. Objective: To determine whether an intervention comprising daily multidisciplinary rounds and monthly audit and feedback meetings performed by a remote board-certified intensivist reduces ICU length of stay (LOS) compared with usual care. Design, Setting, and Participants: A parallel cluster randomized clinical trial with a baseline period in 30 general ICUs in Brazil in which daily multidisciplinary rounds performed by board-certified intensivists were not routinely available. All consecutive adult patients (aged ≥18 years) admitted to the participating ICUs, excluding those admitted due to justice-related issues, were enrolled between June 1, 2019, and April 7, 2021, with last follow-up on July 6, 2021. Intervention: Remote daily multidisciplinary rounds led by a board-certified intensivist through telemedicine, monthly audit and feedback meetings for discussion of ICU performance indicators, and provision of evidence-based clinical protocols. Main Outcomes and Measures: The primary outcome was ICU LOS at the patient level. Secondary outcomes included ICU efficiency, in-hospital mortality, incidence of central line-associated bloodstream infections, ventilator-associated events, catheter-associated urinary tract infections, ventilator-free days at 28 days, patient-days receiving oral or enteral feeding, patient-days under light sedation, and rate of patients with oxygen saturation values under that of normoxemia, assessed using generalized linear mixed models. Results: Among 17 024 patients (1794 in the baseline period and 15 230 in the intervention period), the mean (SD) age was 61 (18) years, 44.7% were female, the median (IQR) Sequential Organ Failure Assessment score was 6 (2-9), and 45.5% were invasively mechanically ventilated at admission. The median (IQR) time under intervention was 20 (16-21) months. Mean (SD) ICU LOS, adjusted for baseline assessment, did not differ significantly between the tele-critical care and usual care groups (8.1 [10.0] and 7.1 [9.0] days; percentage change, 8.2% [95% CI, -5.4% to 23.8%]; P = .24). Results were similar in sensitivity analyses and prespecified subgroups. There were no statistically significant differences in any other secondary or exploratory outcomes. Conclusions and Relevance: Daily multidisciplinary rounds conducted by a board-certified intensivist through telemedicine did not reduce ICU LOS in critically ill adult patients. Trial Registration: ClinicalTrials.gov Identifier: NCT03920501.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu