First naturally occurring homoacridone-flavanone dimers from Glycosmis parviflora .
| Autor: | Ito C; Faculty of Pharmacy, Meijo University, Nagoya, Japan., Matsui T; Faculty of Pharmacy, Meijo University, Nagoya, Japan.; Department of Physiology, Aichi Medical University, Nagakute, Japan., Mamiya K; Faculty of Pharmacy, Meijo University, Nagoya, Japan., Wu TS; Department of Chemistry, National Cheng Kung University, Tainan, Republic of China., Itoigawa M; Tokai Gakuen University, Nagoya, Japan. |
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| Jazyk: | angličtina |
| Zdroj: | Natural product research [Nat Prod Res] 2024 Oct 09, pp. 1-7. Date of Electronic Publication: 2024 Oct 09. |
| DOI: | 10.1080/14786419.2024.2412844 |
| Abstrakt: | The structures of flavacitropones A ( 1 )-B ( 2 ), which are new homoacridone-flavanone dimers from Glycosmis parviflora (Sims) Kurz. (Rutaceae), were elucidated by spectroscopic studies. Flavacitropone A ( 1 ) was evaluated for its biological effects on cytotoxicity and release of histamine and TNF-α in 2,4-dinitrophenyl-human serum albumin-stimulated RBL-2H3 cells (rat basophilic cell line). The compound downregulated TNF-α release, but not histamine release. |
| Databáze: | MEDLINE |
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