Variability of the Microbiota in Chronic Rhinosinusitis: A Scoping Review.

Autor: Ccami-Bernal F; Laboratorio de Microbiología Molecular, Facultad de Medicina Universidad Nacional de San Agustín de Arequipa Arequipa Peru., Barriga-Chambi F; Laboratorio de Microbiología Molecular, Facultad de Medicina Universidad Nacional de San Agustín de Arequipa Arequipa Peru., Ortiz-Benique ZN; Laboratorio de Microbiología Molecular, Facultad de Medicina Universidad Nacional de San Agustín de Arequipa Arequipa Peru., Ferrary E; Université Paris Cité, Institut Pasteur, AP-HP, Inserm, Fondation Pour l'Audition, Institut de l'Audition IHU reConnect Paris France.; Unité Fonctionnelle Implants Auditifs et Explorations Fonctionnelle, Service ORL, GHU Pitié-Salpêtrière AP-HP/Sorbonne Université Paris France., Torres R; Laboratorio de Microbiología Molecular, Facultad de Medicina Universidad Nacional de San Agustín de Arequipa Arequipa Peru.; Université Paris Cité, Institut Pasteur, AP-HP, Inserm, Fondation Pour l'Audition, Institut de l'Audition IHU reConnect Paris France.
Jazyk: angličtina
Zdroj: OTO open [OTO Open] 2024 Oct 08; Vol. 8 (4), pp. e70029. Date of Electronic Publication: 2024 Oct 08 (Print Publication: 2024).
DOI: 10.1002/oto2.70029
Abstrakt: Objective: Chronic rhinosinusitis (CRS) is characterized by a persistent inflammation of the nasal and paranasal sinus mucosa that could be potentially linked to a dysregulation between the microbiota and the immune system. We aim to explore general, methodological, and microbiological aspects of microbiota research in CRS compared to disease-free individuals.
Data Sources: Embase, Ovid MEDLINE, PubMed, Scopus, and Web of Science.
Review Methods: All studies comparing the composition of the resident microbiota of the sinonasal cavities in 2 groups: CRS and normal participants. We conducted systematic study selection, data extraction, and analysis first using the title and abstract, and then the full texts based on predefined inclusion and exclusion criteria. Compiled and presented findings include sampling site and technique, and microbiological results such as the relative abundance and the variability of the composition of the microbiota in both groups.
Results: Twenty-seven studies, using genomic identification with 16s RNA were analyzed. Case definitions primarily followed EPOS or AAO-HNS guidelines, with endoscopic swabs (82%), and middle meatus sampling (74%) being prevalent techniques. Despite relative abundance variability, patterns emerged across studies, indicating an increase in Haemophilus (19%) and Pseudomonas (11%), and decrease in Propionibacterium (15%) and Anaerococcus (11%). Another pattern was observed, showing a decreased alpha diversity (6/19; 22%) in CRS compared to normal individuals.
Conclusion: While variations exist among studies, analysis of CRS microbiota suggests an association with dysbiosis, potentially contributing to chronic inflammation. Future research must prioritize standardized criteria for diagnostics and patient selection, fostering a more comprehensive understanding of CRS microbiota.
Competing Interests: None.
(© 2024 The Author(s). OTO Open published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngology–Head and Neck Surgery Foundation.)
Databáze: MEDLINE
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