Amelanotic Melanoma: A Rare Sinonasal Malignancy.

Autor: Apoorva KV; Department of ENT and Head & Neck Surgery, Kasturba Medical College, Mangalore Manipal Academy of Higher Education, Manipal, India., Bhatia S; Department of ENT and Head & Neck Surgery, Kasturba Medical College, Mangalore Manipal Academy of Higher Education, Manipal, India., Shenoy SV; Department of ENT and Head & Neck Surgery, Kasturba Medical College, Mangalore Manipal Academy of Higher Education, Manipal, India., Hegde S; Department of Pathology, Kasturba Medical College, Mangalore Manipal Academy of Higher Education, Manipal, India., Gowthuvalli C; Department of ENT and Head & Neck Surgery, Kasturba Medical College, Mangalore Manipal Academy of Higher Education, Manipal, India., Aggarwal I; Department of ENT and Head & Neck Surgery, Kasturba Medical College, Mangalore Manipal Academy of Higher Education, Manipal, India.
Jazyk: angličtina
Zdroj: Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India [Indian J Otolaryngol Head Neck Surg] 2024 Oct; Vol. 76 (5), pp. 4765-4769. Date of Electronic Publication: 2024 Jun 29.
DOI: 10.1007/s12070-024-04837-y
Abstrakt: Mucosal melanomas account for less than 1% of all sinonasal malignancies and are aggressive tumours originating from melanocytes in various mucosal epithelia. Diagnosis is often delayed due to nonspecific symptoms, contributing to challenges in treatment and management. We present a case of a 75-year-old female with epistaxis and nasal blockage, ultimately diagnosed with amelanotic sinonasal melanoma. Despite diagnostic difficulties exacerbated by profuse bleeding during biopsy attempts, a comprehensive approach involving clinical evaluation, imaging, and histopathology led to a definitive diagnosis. Immunohistochemistry played a crucial role in confirming the diagnosis, ruling out differential diagnoses such as olfactory neuroblastoma and lymphoma. Surgical excision, despite intraoperative bleeding, was successful, followed by adjuvant chemotherapy and radiotherapy due to the tumor's advanced stage. The case underscores the importance of a multidisciplinary approach and personalized treatment strategies, considering the tumor's molecular characteristics for improved outcomes in managing this rare malignancy.
Competing Interests: Competing InterestsNot applicable.
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Databáze: MEDLINE
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