Evaluation of Withania somnifera (L.) Dunal (Ashwagandha) on Physical Performance, Biomarkers of Inflammation, and Muscle Status in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Study.
| Autor: | Raut A; Clinical Research and Integrative Medicine Department, Kasturba Health Society, Medical Research Centre, Mumbai, IND., Tripathi R; Pharmacology and Therapeutics Department, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, IND., Marathe PA; Pharmacology and Therapeutics Department, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, IND., Uchil DA; Pharmacology and Therapeutics Department, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, IND., Agashe S; Clinical and Endocrine Laboratory, Kasturba Health Society, Medical Research Centre, Mumbai, IND., Rege N; Pharmacology and Therapeutics Department, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, IND., Vaidya AB; Internal Medicine Department, Kasturba Health Society, Medical Research Centre, Mumbai, IND. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Sep 08; Vol. 16 (9), pp. e68940. Date of Electronic Publication: 2024 Sep 08 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.68940 |
| Abstrakt: | Background: Sarcopenia is associated with chronic inflammation, a sedentary lifestyle, and ageing. However, there exists no drug, which is safe and effective for long-term use. Ashwagandha ( Withaniasomnifera (L.) Dunal) has the potential to fill this therapeutic gap based on its efficacy and safety profile; hence, the present study was planned to evaluate its effect on inflammatory biomarkers and muscle status in healthy volunteers. Methodology: A prospective, double-blind, randomized, placebo-controlled clinical study was conducted to evaluate the effects of Ashwagandha extract in healthy volunteers (February 2021 to May 2022) who received either Ashwagandha extract tablets 250 mg or a placebo twice daily for 60 days. The physical performance on a bicycle ergometer, inflammatory/muscle status biomarkers, body composition, reaction time, hemogram, and organ function tests was assessed at baseline, day 30, and day 60. Results: In the Ashwagandha group, there was a statistically significant (p<0.05) improvement in total distance travelled (Ashwagandha 2.85 ± 0.54 km vs placebo 2.16 ± 0.62 km), average speed achieved (Ashwagandha 25.6 ± 5.7 km/hour vs placebo 22.2 ± 5.48 km/hour) on a bicycle ergometer from the baseline visit (V3) to the last visit (V7) as compared to the placebo group. The observations on hand-grip strength, back-leg press, skeletal muscle mass, and VO Conclusion: Ashwagandha extract supplementation was safe and effective in enhancing physical performance and strengthening muscle mass and could be a potential candidate for treating sarcopenia. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College issued approval EC/OA-159/2018; approval dated 9/7/2019. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Raut et al.) |
| Databáze: | MEDLINE |
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