The epidemiology and impact of persistent Campylobacter infections on childhood growth among children 0-24 months of age in resource-limited settings.

Autor:	Schiaffino F; Faculty of Veterinary Medicine, Universidad Peruana Cayetano Heredia, San Martin de Porres, Lima, Peru.; Division of Infectious Diseases and International Health, School of Medicine, University of Virginia, Charlottesville, VA, USA., Colston JM; Division of Infectious Diseases and International Health, School of Medicine, University of Virginia, Charlottesville, VA, USA., Paredes Olortegui M; Asociacion Benefica Prisma, Iquitos, Peru., Peñataro Yori P; Division of Infectious Diseases and International Health, School of Medicine, University of Virginia, Charlottesville, VA, USA.; Asociacion Benefica Prisma, Iquitos, Peru., Mourkas E; Ineos Oxford Institute for Antimicrobial Research, Department of Biology, University of Oxford, Oxford, United Kingdom., Pascoe B; Ineos Oxford Institute for Antimicrobial Research, Department of Biology, University of Oxford, Oxford, United Kingdom.; Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, United Kingdom., Lima AAM; Institute of Biomedicine for Brazilian Semiarid, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil., Mason CJ; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Ahmed T; Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Kang G; Wellcome Research Unit, Christian Medical College, Vellore, India., Mduma E; Haydom Lutheran Hospital, Manraya, Tanzania., Samie A; University of Venda, Limpopo Province, South Africa., Zaidi A; Division of Women and Child Health, Aga Khan University, Karachi, Pakistan., Liu J; Division of Infectious Diseases and International Health, School of Medicine, University of Virginia, Charlottesville, VA, USA.; School of Public Health, Qingdao University, Qingdao, China., Cooper KK; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, USA., Houpt ER; Division of Infectious Diseases and International Health, School of Medicine, University of Virginia, Charlottesville, VA, USA., Parker CT; Agricultural Research Service, U.S. Department of Agriculture, Produce Safety and Microbiology Research Unit, Albany, CA, USA., Lee GO; Rutgers Global Health Institute & Department of Biostatistics and Epidemiology, School of Public Health, Rutgers the State University of New Jersey, Newark, NJ, USA., Kosek MN; Division of Infectious Diseases and International Health, School of Medicine, University of Virginia, Charlottesville, VA, USA.; Asociacion Benefica Prisma, Iquitos, Peru.
Jazyk:	angličtina
Zdroj:	EClinicalMedicine [EClinicalMedicine] 2024 Sep 28; Vol. 76, pp. 102841. Date of Electronic Publication: 2024 Sep 28 (Print Publication: 2024).
DOI:	10.1016/j.eclinm.2024.102841
Abstrakt:	Background: Campylobacter is the leading cause of bacterial gastroenteritis worldwide. It is generally associated with an acute gastrointestinal infection causing a self-limiting diarrheal episode. However, there is evidence that persistent/recurrent carriage of Campylobacter also occurs. In hyperendemic settings the epidemiology and consequences of persistent Campylobacter enteric infections is poorly studied. Methods: Risk factors for and growth consequences of persistent Campylobacter infections detected by polymerase chain reaction (qPCR) were evaluated with data from the MAL-ED birth cohort study in children 0-24 months of age between November 2009 and February 2012. A persistent Campylobacter infection was defined as three or more consecutive Campylobacter positive monthly stools. Findings: Across all study sites, 45.5% (781/1715) of children experienced at least one persistent Campylobacter episode. The average cumulative duration of days in which children with persistent Campylobacter were positive for Campylobacter spp. was 150 days (inter-quartile range: 28-236 days). Children who experienced a persistent Campylobacter episode had an attained 24-month length-for-age (LAZ) score that was 0.23 (95% (CI): -0.31, -0.15) less than children without a persistent Campylobacter episode. Among children who had at least one episode of Campylobacter over a 3-month or 9-month window, persistent episodes were not significantly associated with poorer 3-month weight gain (-28.7 g, 95% CI: -63.4 g, 6.0 g) but were associated with poorer 9-month linear growth (-0.134 cm 95% CI: -0.246, -0.022) compared to children with an episode that resolved within 31 days. Interpretation: Persistent/recurrent Campylobacter infection is common among children and has a measurable negative impact on linear growth in early childhood. Funding: Funding for this study was provided by the Bill and Melinda Gates Foundation (OPP1066146 and OPP1152146), the National Institutes of Health United States (R01AI158576 and R21AI163801 to MNK and CTP; K43TW012298 to FS; K01AI168493 to JMC; GOL was supported by K01AI145080. This research was also supported in part by USDA-ARS CRIS project 2030-42000-055-00D. The funders had no role in study design, study implementation, data analysis, or interpretation of the results. Competing Interests: AKZ is currently employed at the Bill and Melinda Gates Foundation as the President of Gender Equality. The Gates Foundation was the original funder of this project. They have not had a role in this analysis. (© 2024 The Author(s).)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu