The Neurocircuitry of Substance Use Disorder, Treatment, and Change: A Resource for Clinical Psychiatrists.

Autor:	Imperio CG; Division on Substance Use Disorders, New York State Psychiatric Institute, New York; Department of Psychiatry, Columbia University Irving Medical Center, New York., Levin FR; Division on Substance Use Disorders, New York State Psychiatric Institute, New York; Department of Psychiatry, Columbia University Irving Medical Center, New York., Martinez D; Division on Substance Use Disorders, New York State Psychiatric Institute, New York; Department of Psychiatry, Columbia University Irving Medical Center, New York.
Jazyk:	angličtina
Zdroj:	The American journal of psychiatry [Am J Psychiatry] 2024 Nov 01; Vol. 181 (11), pp. 958-972. Date of Electronic Publication: 2024 Oct 09.
DOI:	10.1176/appi.ajp.20231023
Abstrakt:	Substance use disorder (SUD) is common in psychiatric patients and has a negative impact on health and well-being. However, SUD often goes untreated, and there is a need for psychiatrists, of all specialties, to address this pervasive clinical problem. In this review, the authors' goal is to provide a resource that describes treatments for SUD, using neuroscience as a framework. They discuss the effect of pharmacotherapy on craving, intoxication, and withdrawal and its ability to interrupt the cycle of substance use in SUD. The neuroscience of stress is reviewed, including medications targeting neurotransmitter systems activated by alarm and fear. Neuroplasticity and promising treatments that use this mechanism, including ketamine, psilocybin, and transcranial magnetic stimulation (TMS), are discussed. The authors conclude by listing resources and practice guidelines for physicians interested in learning more about treatments for SUD. Competing Interests: Dr. Levin has received grant support from the National Center for Advancing Translational Sciences, NIDA, SAMHSA, and US WorldMeds and research support from Aelis Pharmaceuticals; she has received medication from Indivior for research; she has served on the National Advisory Council on Alcohol Abuse and Alcoholism and as a nonpaid member of scientific advisory boards for Alkermes, Atai Life Science, Boehringer Ingelheim, Indivior, Novartis, Teva, and US WorldMeds; she has served as a consultant for Major League Baseball; and she receives royalties from APA Publishing. The other authors report no financial relationships with commercial interests.
Databáze:	MEDLINE
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