Prognostic Nutritional Index is Related to All-Cause Mortality in Patients With Stage IV Colorectal Cancer Treated With Capecitabine: Single-Center 24-Month Observational Study in Vietnam.

Autor: Nguyen Quang H; Oncology Center, Bach Mai Hospital, Ha Noi, Vietnam., Nguyen Duc L; Oncology Center, Bach Mai Hospital, Ha Noi, Vietnam., Hoang Van H; Oncology Center, Bach Mai Hospital, Ha Noi, Vietnam., Vu Anh H; Military Hospital 103, Ha Noi, Vietnam.; Vietnam Military Medical University, Ha Noi, Vietnam., Nguyen Trung K; Military Hospital 103, Ha Noi, Vietnam.; Vietnam Military Medical University, Ha Noi, Vietnam., Le Viet T; Military Hospital 103, Ha Noi, Vietnam.; Vietnam Military Medical University, Ha Noi, Vietnam.
Jazyk: angličtina
Zdroj: Journal of clinical laboratory analysis [J Clin Lab Anal] 2024 Nov; Vol. 38 (21), pp. e25112. Date of Electronic Publication: 2024 Oct 08.
DOI: 10.1002/jcla.25112
Abstrakt: Aim: To determine the mortality rate and the predictive value of the prognostic nutritional index (PNI) for all-cause mortality during the 24 months in patients with stage IV colorectal cancer treated with capecitabine.
Methods: We conducted a study on 87 stage IV colorectal cancer patients treated with capecitabine. Before the day of treatment, all patients were measured CEA and CRP-hs levels and calculated neutrophil/lympho ratio (NLR) and PNI. Patients were monitored and collected drug side effects and mortality for 24 months.
Results: The mortality rate of study subjects was 60.9%. CRP-hs, NLR, and PNI were independent factors associated with 24-month mortality in patients with stage IV colorectal cancer (p < 0.05 to p < 0.01). At a cut-off value of 38.51, PNI was a predictor for mortality, with the area under the curve (AUC) of 0.88 and p < 0.001.
Conclusions: PNI was a good predictor of all-cause mortality in patients with stage IV colorectal cancer treated with capecitabine for 24 months.
(© 2024 The Author(s). Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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