Systematic review and Meta-analysis of brain plasticity associated with electroacupuncture in experimental ischemic stroke.

Autor:	Yingshan XU; College of Acupuncture and Massage, Shaanxi University of Chinese Medicine, Middle Section of Century Avenue, Xianyang 712046, China., Chunxiao WU; Department of Encephalopathy, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen 518000, China., Wei YU; Department of Obstetrics and Gynecology, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen 518034, China., Hongji G; Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Liming LU; Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Nenggui XU; Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Chunzhi T; Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Jazyk:	angličtina
Zdroj:	Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan [J Tradit Chin Med] 2024 Oct; Vol. 44 (5), pp. 859-870.
DOI:	10.19852/j.cnki.jtcm.20240828.008
Abstrakt:	Objective: To systematically evaluate the role of electroacupuncture in maintaining brain plasticity in ischemic stroke mediated brain damage. Methods: We searched for all relevant trials published through Oct 7, 2022 from seven databases. Metho-dological quality was assessed using the CAMARADES Risk of Bias Tool. A Meta-analysis of comparative effects was performed using Review Manager v.5.3 software. Results: A total of 101 studies involving 2148 animals were included. For most studies, primary outcomes results of the Meta-analysis indicate that EA significantly improved ischemic stroke rat's postsynaptic density thickness [Standardized Mean Difference ( SMD ) = 1.41, 95% confidence interval ( CI ) (0.59, 2.23), P = 0.0008], numerical density of synapses [ SMD = 1.55, 95% CI (0.48, 2.63), P = 0.005] compared with non-EA-treated. Similarly, EA could improve parts of biomarkers of synapses, neurogenesis, angiogenesis and neurotrophin activity than the control group ( P < 0.05). Conclusion: The existing evidence suggests EA regulating ischemic stroke may be through brain plasticity. More rigorous and high quality studies should be conducted in the future.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu