The O-GlcNAc database: introducing new features and tools developed from community feedback.

Autor: Malard F; INSERM U1212, CNRS UMR5320, ARNA Laboratory, University of Bordeaux, Bordeaux, France., Massman L; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Campagne S; INSERM U1212, CNRS UMR5320, ARNA Laboratory, University of Bordeaux, Bordeaux, France., Olivier-Van Stichelen S; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. solivier@mcw.edu.; Department of Obstetrics & Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. solivier@mcw.edu.; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. solivier@mcw.edu.
Jazyk: angličtina
Zdroj: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2024 Oct 08. Date of Electronic Publication: 2024 Oct 08.
DOI: 10.1007/s00216-024-05571-8
Abstrakt: O-GlcNAc is a reversible post-translational modification found on serine and threonine residues of nucleocytoplasmic proteins. Four years ago, we released the O-GlcNAc Database ( oglcnac.mcw.edu ), a comprehensive catalog of O-GlcNAcylated proteins that has become one of the most cited resources in the field, with hundreds of unique users per month. We are now presenting an updated O-GlcNAc Database, which includes nearly 20,000 O-GlcNAcylated proteins and 48 species, marking substantial growth in data volume and scope. This paper presents the most noteworthy features implemented over the last year, often originating from feedback from the O-GlcNAc community. Among these features, we provide a brief overview of the database content, introduce our new protein viewer mode, and discuss the implementation of subcellular localization information and its applications in the O-GlcNAc score. We also provide an interface to use CytOVS, a tool designed to evaluate and sort O-GlcNAcome datasets derived from MS experiments. In conclusion, this new and improved O-GlcNAc Database represents a significant advancement in providing a comprehensive and expanded resource for researchers in the field of O-GlcNAc biology.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.)
Databáze: MEDLINE
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