Effect of childhood atropine treatment on adult choroidal thickness using sequential deep learning-enabled segmentation.

Autor:	Li Y; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore., Wong D; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; SERI-NTU Advanced Ocular Engineering (STANCE), Singapore, Singapore; School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore., Sreng S; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; SERI-NTU Advanced Ocular Engineering (STANCE), Singapore, Singapore., Chung J; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Toh A; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Yuan H; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore., Eppenberger LS; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Leow C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Ting D; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore; Byers Eye Institute, Sandford University, Palo Alto, CA, USA., Liu N; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore., Schmetterer L; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore; SERI-NTU Advanced Ocular Engineering (STANCE), Singapore, Singapore; School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore; Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria; Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Vienna, Austria; Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland., Saw SM; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Jonas JB; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland; Privatpraxis Prof Jonas and Dr Panda-Jonas, Heidelberg, Germany., Chia A; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore., Ang M; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore. Electronic address: marcus.ang@snec.com.sg.
Jazyk:	angličtina
Zdroj:	Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) [Asia Pac J Ophthalmol (Phila)] 2024 Sep-Oct; Vol. 13 (5), pp. 100107. Date of Electronic Publication: 2024 Oct 06.
DOI:	10.1016/j.apjo.2024.100107
Abstrakt:	Purpose: To describe choroidal thickness measurements using a sequential deep learning segmentation in adults who received childhood atropine treatment for myopia control. Design: Prospective, observational study. Methods: Choroidal thickness was measured by swept-source optical coherence tomography in adults who received childhood atropine, segmented using a sequential deep learning approach. Results: Of 422 eyes, 94 (22.3 %) had no previous exposure to atropine treatment, while 328 (77.7 %) had received topical atropine during childhood. After adjusting for age, sex, and axial length, childhood atropine exposure was associated with a thicker choroid by 32.1 μm (95 % CI, 9.2-55.0; P = 0.006) in the inner inferior, 23.5 μm (95 % CI, 1.9-45.1; P = 0.03) in the outer inferior, 21.8 μm (95 % CI, 0.76-42.9; P = 0.04) in the inner nasal, and 21.8 μm (95 % CI, 2.6-41.0; P = 0.03) in the outer nasal. Multivariable analysis, adjusted for age, sex, atropine use, and axial length, showed an independent association between central subfield choroidal thickness and the incidence of tessellated fundus (P < 0.001; OR, 0.97; 95 % CI, 0.96-0.98). Conclusions: This study demonstrated that short-term (2-4 years) atropine treatment during childhood was associated with an increase in choroidal thickness of 20-40 μm in adulthood (10-20 years later), after adjusting for age, sex, and axial length. We also observed an independent association between eyes with thicker central choroidal measurements and reduced incidence of tessellated fundus. Our study suggests that childhood exposure to atropine treatment may affect choroidal thickness in adulthood. Competing Interests: Declaration of Competing Interest Dr Jost B. Jonas has disclosed European patent EP 3 271 392, JP 2021–119187, and US 2021 0340237 A1: Agents for use in the therapeutic or prophylactic treatment of myopia or hyperopia. Dr Audrey Chia has disclosed royalties from Myopine. Dr Leopold Schmetterer has disclosed consultancy fee from Thea Pharma. (Copyright © 2024. Published by Elsevier Inc.)
Databáze:	MEDLINE
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