Removal of acetyl-rich impurities from chitosan using liquefied dimethyl ether.
Autor: | Wang T; Department of Chemical Systems Engineering, Nagoya University, Nagoya 464-8603, Japan., Kusumi K; Department of Materials Process Engineering, Nagoya University, Nagoya 464-8603, Japan., Zhu L; Department of Chemical Systems Engineering, Nagoya University, Nagoya 464-8603, Japan., Mei L; Department of Chemical Systems Engineering, Nagoya University, Nagoya 464-8603, Japan., Manabe A; Department of Chemical Systems Engineering, Nagoya University, Nagoya 464-8603, Japan., Asghari M; Department of Chemical Systems Engineering, Nagoya University, Nagoya 464-8603, Japan; Department of Mechanical Engineering of Biosystem, Shahrekord University, Iran., Samani BH; Department of Mechanical Engineering of Biosystem, Shahrekord University, Iran., Yamamoto T; Department of Chemical Systems Engineering, Nagoya University, Nagoya 464-8603, Japan., Kanda H; Department of Chemical Systems Engineering, Nagoya University, Nagoya 464-8603, Japan. Electronic address: kanda.hideki@material.nagoya-u.ac.jp. |
---|---|
Jazyk: | angličtina |
Zdroj: | International journal of biological macromolecules [Int J Biol Macromol] 2024 Nov; Vol. 280 (Pt 4), pp. 136381. Date of Electronic Publication: 2024 Oct 06. |
DOI: | 10.1016/j.ijbiomac.2024.136381 |
Abstrakt: | Chitosan, recognized for its excellent biodegradability, biocompatibility, and antibacterial properties, has several potential applications, particularly in the biomedical field. However, its widespread use is hindered by inherent limitations such as low mechanical strength and safety concerns arising from a low degree of deacetylation and the presence of impurities. This study aimed to introduce an innovative purification method for chitosan via liquefied dimethyl ether (DME) extraction. The proposed technique effectively addresses the challenges associated with chitosan by facilitating deacetylation and impurity removal. Liquefied DME is emerging as the extraction solvent of choice owing to its advantages, such as low boiling point, safety, and environmental sustainability. The degree of deacetylation of chitosan was extensively evaluated using thermogravimetric-differential thermal analysis, Fourier transform infrared spectroscopy, X-ray diffraction, intrinsic viscosity measurements, solid-state nuclear magnetic resonance spectroscopy and X-ray photoelectron spectroscopy, and elemental analysis. The solubility of chitosan in liquefied DME was investigated using Hansen solubility parameters. This study contributes to the improvement of the safety profile of chitosan, thereby expanding its potential applications in various fields. The use of liquefied DME as an extraction solvent proved to be efficient in addressing the existing challenges and is consistent with the principles of safety and environmental sustainability. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
Externí odkaz: |