Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy.

Autor:	Del Cerro-León A; Center of Cognitive and Computational Neuroscience, Universidad Complutense de Madrid, Madrid 28040, Spain.; Department of Experimental Psychology, Cognitive Processes and Speech Therapy, Faculty of Psychology, Universidad Complutense de Madrid, Madrid 28040, Spain., Fernando Antón-Toro L; Center of Cognitive and Computational Neuroscience, Universidad Complutense de Madrid, Madrid 28040, Spain.; Department of Psychology, University Camilo José Cela, Madrid 28692, Spain., Shpakivska-Bilan D; Center of Cognitive and Computational Neuroscience, Universidad Complutense de Madrid, Madrid 28040, Spain.; Department of Experimental Psychology, Cognitive Processes and Speech Therapy, Faculty of Psychology, Universidad Complutense de Madrid, Madrid 28040, Spain., Uceta M; Center of Cognitive and Computational Neuroscience, Universidad Complutense de Madrid, Madrid 28040, Spain.; Department of Cellular Biology, Faculty of Biology, Complutense University of Madrid, Madrid 28040, Spain., Santos-Mayo A; Center of Cognitive and Computational Neuroscience, Universidad Complutense de Madrid, Madrid 28040, Spain.; Department of Psychology, University of Florida, Gainesville, FL 32612., Cuesta P; Center of Cognitive and Computational Neuroscience, Universidad Complutense de Madrid, Madrid 28040, Spain.; Health Research Institute of the Hospital Clínico San Carlos (IdISSC), Madrid 28040, Spain.; Department of Radiology, Faculty of Medicine, Complutense University of Madrid, Madrid 28040, Spain., Bruña R; Center of Cognitive and Computational Neuroscience, Universidad Complutense de Madrid, Madrid 28040, Spain.; Department of Radiology, Faculty of Medicine, Complutense University of Madrid, Madrid 28040, Spain., García-Moreno LM; Department of Psychobiology and Methodology in Behavioral Science, Faculty of Education, Complutense University of Madrid, Madrid 28040, Spain., Maestú F; Center of Cognitive and Computational Neuroscience, Universidad Complutense de Madrid, Madrid 28040, Spain.; Department of Experimental Psychology, Cognitive Processes and Speech Therapy, Faculty of Psychology, Universidad Complutense de Madrid, Madrid 28040, Spain.; Department of Psychology, University of Florida, Gainesville, FL 32612.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct 15; Vol. 121 (42), pp. e2320805121. Date of Electronic Publication: 2024 Oct 08.
DOI:	10.1073/pnas.2320805121
Abstrakt:	Alcohol consumption during adolescence has been associated with neuroanatomical abnormalities and the appearance of future disorders. However, the latest advances in this field point to the existence of risk profiles which may lead to some individuals into an early consumption. To date, some studies have established predictive models of consumption based on sociodemographic, behavioral, and anatomical-functional variables using MRI. However, the neuroimaging variables employed are usually restricted to local and hemodynamic phenomena. Given the potential of connectome approaches, and the high temporal dynamics of electrophysiology, we decided to explore the relationship between future alcohol consumption and electrophysiological connectivity measured by MEG in a cohort of 83 individuals aged 14 to 16. As a result, we found a positive correlation between alcohol consumption and the functional connectivity in frontal, parietal, and frontoparietal connections. Once this relationship was described, multivariate linear regression analyses were used to evaluate the predictive capacity of functional connectivity in conjunction with other neuroanatomical and behavioral variables described in the literature. Finally, the multivariate linear regression analysis determined the importance of anatomical and functional variables in the prediction of alcohol consumption but failed to find associations with impulsivity, sensation seeking, and executive function scales. In conclusion, the predictive traits obtained in these models were closely associated with changes occurring during adolescence, suggesting the existence of different paths in neurodevelopment that have the potential to influence adolescents' relationship with alcohol consumption. Competing Interests: Competing interests statement:The authors declare no competing interest.
Databáze:	MEDLINE
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