A review of the fighting Acinetobacter baumannii on three fronts: antibiotics, phages, and nanoparticles.

Autor: Teymouri S; Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Pourhajibagher M; Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. m-pourhajibagher@sina.tums.ac.ir.; Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran. m-pourhajibagher@sina.tums.ac.ir., Bahador A; Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. abahador@sina.tums.ac.ir.; Fellowship in Clinical Laboratory Sciences, BioHealth Lab, Tehran, Iran. abahador@sina.tums.ac.ir.
Jazyk: angličtina
Zdroj: Molecular biology reports [Mol Biol Rep] 2024 Oct 08; Vol. 51 (1), pp. 1044. Date of Electronic Publication: 2024 Oct 08.
DOI: 10.1007/s11033-024-09979-4
Abstrakt: In the current era of antibiotic resistance, researchers are exploring alternative ways to treat bacterial infections that are resistant to multiple drugs. Acinetobacter baumannii (A. baumannii) is a bacterium that is commonly encountered in clinical settings and is known to be resistant to several drugs. Due to the increase in drug-resistant infections caused by this bacteria, there is an urgent need to investigate alternative treatment options such as phage therapy and combination therapy. Despite the success of phages in some cases, there are some limitations in their clinical application that can be overcome by combining phages with other substrates such as nanoparticles to improve their function. The integration of nanotechnology with phage therapy against A. baumannii promises to overcome antibiotic resistance. By exploiting the targeted delivery and controlled release capabilities of nanoparticles, we can enhance the therapeutic potential of phages while minimizing their limitations. Continued research in this field will undoubtedly pave the way for more effective and precise treatments against A. baumannii infections and provide hope in the fight against antibiotic-resistant bacteria.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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