Paraneoplastic systemic lupus erythematosus associated with dysgerminoma: a case report and literature review.

Autor: Ben David R; Internal Medicine Division, Soroka Univerity Medical Center, Beer-Sheva, Israel. ranbendavid@gmail.com.; Rheumatic Diseases Unit, Soroka University Medical Center, Beer Sheva, Israel. ranbendavid@gmail.com., Abu-Shakra M; Internal Medicine Division, Soroka Univerity Medical Center, Beer-Sheva, Israel.; Rheumatic Diseases Unit, Soroka University Medical Center, Beer Sheva, Israel., Meirovitz M; Unit of Gynecologic Oncology, Soroka Medical Center, Beer Sheva, Israel., Test T; Clalit Health Services, Southern District, Beer-Sheva, Israel.; Department of Family Medicine, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel., Medvedev N; Clalit Health Services, Southern District, Beer-Sheva, Israel.; Institute of Pathology, Soroka University Medical Centre, Beer-Sheva, Israel., Sagy I; Internal Medicine Division, Soroka Univerity Medical Center, Beer-Sheva, Israel.; Rheumatic Diseases Unit, Soroka University Medical Center, Beer Sheva, Israel.
Jazyk: angličtina
Zdroj: Internal and emergency medicine [Intern Emerg Med] 2024 Oct 08. Date of Electronic Publication: 2024 Oct 08.
DOI: 10.1007/s11739-024-03790-6
Abstrakt: Rheumatic paraneoplastic syndromes are rare and generally occur no longer than two years before diagnosis of the associated malignancy. Therefore, it can be an essential clue to occult malignancy. A healthy 18-year-old female with no underlying diseases was referred to the rheumatology clinic due to morning stiffness in her hands and a new rash on her fingers. Her labs showed a positive ANA, anti-double strand DNA antibody, anti-RNP, and anti-ribosomal P. Nine months after the diagnosis with SLE, the patient presented with elevated levels of lactate dehydrogenase. A total-body computed tomography scan revealed a solid mass in the pelvis. The pathological findings corresponded to a dysgerminoma tumor. Following surgical tumor removal and chemotherapy, the patient went into remission with both SLE and her oncology conditions, with no relapse of her lupus symptoms in a one-year follow-up. This case underscores the importance of considering malignancy in unexplained lupus symptoms, a crucial point for all physicians to be aware of. We identified 13 cases of paraneoplastic SLE in a literature review. In most cases, SLE is resolved after the tumor has been treated.
(© 2024. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).)
Databáze: MEDLINE
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