LEAP! Rx: A randomized trial of a pragmatic approach to lifestyle medicine.

Autor: Watts A; Department of Psychology, University of Kansas, Lawrence, Kansas, USA.; University of Kansas Alzheimer's Disease Research Center, Fairway, Kansas, USA., Szabo-Reed A; Physical Activity & Weight Management, University of Kansas Medical Center, Kansas City, Kansas, USA., Baker J; Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA., Morris JK; University of Kansas Alzheimer's Disease Research Center, Fairway, Kansas, USA., Vacek J; Department of Cardiovascular Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA., Clutton J; University of Kansas Alzheimer's Disease Research Center, Fairway, Kansas, USA., Mahnken J; Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA., Key MN; University of Kansas Alzheimer's Disease Research Center, Fairway, Kansas, USA., Vidoni ED; University of Kansas Alzheimer's Disease Research Center, Fairway, Kansas, USA., Burns JM; University of Kansas Alzheimer's Disease Research Center, Fairway, Kansas, USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Oct 08. Date of Electronic Publication: 2024 Oct 08.
DOI: 10.1002/alz.14265
Abstrakt: Introduction: Clinicians lack the tools to incorporate physical activity into clinical care for Alzheimer's disease prevention. We tested a 52-week exercise and health education program (Lifestyle Empowerment for Alzheimer's Prevention [LEAP! Rx]) that integrates clinician referrals and community-based fitness resources.
Methods: We randomized 219 participants to the LEAP! Rx (ie, exercise and monthly brain health education) or a standard-of-care control group and tested the effects on cardiorespiratory fitness, insulin resistance, body composition, lipids, and cognitive performance.
Results: Physicians were able to connect their patients to a community lifestyle intervention. The intervention group increased in cardiorespiratory fitness at 12 and 52 weeks (p = 0.005). We observed no effects on secondary measures. Participants meeting 80% of weekly goals (150 min, moderate to vigorous activity) saw greater fitness improvements than those with less than 80% (p < 0.001).
Discussion: These results hold promise for broad implementation of exercise interventions into larger healthcare systems and have implications for improved research recruitment strategies.
Trial Registration: NCT No. NCT03253341.
Highlights: Our community-based exercise program increased cardiorespiratory fitness. Our digital physician referral method increased the diversity of the participant sample. Our findings have implications for personalized dementia risk reduction strategies.
(© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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