Comparative In Vivo Biocompatibility of Cellulose-Derived and Synthetic Meshes in Subcutaneous Transplantation Models.

Autor: Peltokallio NMM; Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Viikintie 49, FI-00014 Helsinki University, Finland., Ajdary R; Biobased Colloids and Materials, Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, P.O. Box 16300, FI-00076 Aalto, Espoo,Finland., Reyes G; Biobased Colloids and Materials, Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, P.O. Box 16300, FI-00076 Aalto, Espoo,Finland., Kankuri E; Department of Pharmacology, Faculty of Medicine, University of Helsinki, P.O. Box 29, Helsinki 00014, Finland., Junnila JJT; EstiMates Oy, Kamreerintie 8, FI-022770 Espoo, Finland., Kuure S; GM unit, Helsinki Institute of Life Science/STEMM, Research Program's Unit, Faculty of Medicine, University of Helsinki, P.O. Box 63, Helsinki 00014, Finland., Meller AS; Laboratory Animal Centre, HiLIFE, University of Helsinki, P.O. Box 29, Helsinki 00014, Finland., Kuula J; Department of Neuroscience and Biomedical Engineering, School of Science, Aalto University, P.O. Box 16300, FI-00076 Aalto, Espoo, Finland., Raussi-Lehto E; Department of Neuroscience and Biomedical Engineering, School of Science, Aalto University, P.O. Box 16300, FI-00076 Aalto, Espoo, Finland.; Customer-oriented Wellbeing and Health Services, Metropolia University of Applied Sciences, PL 4000, FI-00079 Metropolia, Helsinki,Finland., Sariola H; Department of Pathology, Faculty of Medicine, University of Helsinki, P.O. Box 63, Helsinki 00014, Finland., Laitinen-Vapaavuori OM; Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Viikintie 49, FI-00014 Helsinki University, Finland., Rojas OJ; Biobased Colloids and Materials, Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, P.O. Box 16300, FI-00076 Aalto, Espoo,Finland.; Bioproducts Institute, Department of Chemical and Biological Engineering, The University of British Columbia, 2360 East Mall, Vancouver, BC V6T 1Z3, Canada.; Department of Wood Science, University of British Columbia, 2385 East Mall, Vancouver, BC V6T 1Z4, Canada.; Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Jazyk: angličtina
Zdroj: Biomacromolecules [Biomacromolecules] 2024 Nov 11; Vol. 25 (11), pp. 7298-7310. Date of Electronic Publication: 2024 Oct 08.
DOI: 10.1021/acs.biomac.4c00984
Abstrakt: Despite the increasing interest in cellulose-derived materials in biomedical research, there remains a significant gap in comprehensive in vivo analyses of cellulosic materials obtained from various sources and processing methods. To explore durable alternatives to synthetic medical meshes, we evaluated the in vivo biocompatibility of bacterial nanocellulose, regenerated cellulose, and cellulose nanofibrils in a subcutaneous transplantation model, alongside incumbent polypropylene and polydioxanone. Notably, this study demonstrates the in vivo biocompatibility of regenerated cellulose obtained through alkali dissolution and subsequent regeneration. All cellulose-derived implants triggered the expected foreign body response in the host tissue, characterized predominantly by macrophages and foreign body giant cells. Porous materials promoted cell ingrowth and biointegration. Our results highlight the potential of bacterial nanocellulose and regenerated cellulose as safe alternatives to commercial polypropylene meshes. However, the in vivo fragmentation observed for cellulose nanofibril meshes suggests the need for measures to optimize their processing and preparation.
Databáze: MEDLINE