Oral/Perioral Reactions to Injectable Soft Tissue Fillers: A Clinicopathological Multicentric Study.

Autor: Pires FR; Oral Pathology, School of Dentistry, Rio de Janeiro State University, and Post Graduation Program in Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil., Said AMT; Post Graduation Program in Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil., Netto JNS; Stomatology, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., da Cruz Perez DE; Oral Pathology Unit, School of Dentistry, Federal University of Pernambuco, Recife, Brazil., Bonan PRF; Department of Clinics and Social Dentistry, Federal University of Paraíba, João Pessoa, Brazil., Martins HDD; Department of Clinics and Social Dentistry, Federal University of Paraíba, João Pessoa, Brazil., Kaminagakura E; Department of Bioscience and Oral Diagnosis, São Paulo State University, São José dos Campos, Brazil., Alves FA; Stomatology, AC Camargo Cancer Center, São Paulo, Brazil., Martelli Júnior H; Stomatology Clinic, Dental School, State University of Montes Claros, Montes Claros, Brazil., Machado RA; Graduate Program in Oral Biology, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil., Lopes MA; Semiology, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil., Santos-Silva AR; Semiology, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil., Vargas PA; Oral Pathology, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil., Louredo BVR; Oral Pathology, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil., Vega-Memije ME; Dermatology Department, Hospital General Dr. Manuel Gea González, Mexico City, Mexico., Cano-Aguilar LE; Dermatology Department, Hospital General Dr. Manuel Gea González, Mexico City, Mexico., Toussaint-Caire S; Dermatopathology, Dermatology Department, Hospital General Dr. Manuel Gea González, Mexico City, Mexico., Monteiro MDS; Oral Pathology, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Fonseca TC; Oral Pathology, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Romañach MJ; Oral Pathology, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Abrahão AC; Oral Pathology, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Aguirre-Urizar JM; Oral Pathology and Medicine, Department of Stomatology, University of the Basque Country, Bilbao, Spain., Lafuente Ibáñez-de-Mendoza I; Oral Pathology and Medicine, Department of Stomatology, University of the Basque Country, Bilbao, Spain., Olmedo-Campos M; Private Practice, Mexico City, Mexico., Mosqueda-Taylor A; Health Care Department, Metropolitan Autonomous University Xochimilco, Mexico City, Mexico.
Jazyk: angličtina
Zdroj: Oral diseases [Oral Dis] 2024 Oct 07. Date of Electronic Publication: 2024 Oct 07.
DOI: 10.1111/odi.15143
Abstrakt: Objective: To analyze the characteristics of a series of oral reactions to injectable soft tissue fillers.
Materials and Methods: Cases diagnosed as oral reactions to injectable soft tissue fillers were selected from eight Pathology laboratories. Information was retrieved from the laboratory charts and from the review of the hematoxylin and eosin-stained histological slides.
Results: The 151 patients showed a mean age of 54.9 years, and 136 (90.1%) were females. Mean time of onset was 20.4 months, and the lips were the most frequent location (72.8%). Most cases presented as asymptomatic isolated nodules, with a mean size of 17.4 mm. Silicone (38.5%), polymethylmetacrylate (33%), and hyaluronic acid (11.9%) were the three most common fillers. Granulomas, foamy macrophages, and multinucleated giant cells were observed in 44%, 51.5%, and 65.3% of the cases, respectively. Time of onset was shorter for males (p = 0.033), and symptoms were common in the upper lip, buccal mucosa, and lower vestibule (p = 0.010). Foamy macrophages were more common in association with silicone and collagen (p < 0.001), whereas multinucleated giant cells were more common in association with polymethylmetacrylate, hydroxiapatite, and polylactic acid (p = 0.012).
Conclusion: Clinicians should consider reactions to injectable soft tissue fillers when evaluating asymptomatic submucosal nodules affecting the lips of adult/older females.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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