Outstanding increase in tumor-to-background ratio over time allows tumor localization by [ 89 Zr]Zr-PSMA-617 PET/CT in early biochemical recurrence of prostate cancer.

Autor: Burgard C; Departments of Nuclear Medicine, Saarland University - Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany. caroline.burgard@uks.eu.; Saarland University, USAAR, Saarbrücken, Germany. caroline.burgard@uks.eu., Rosar F; Departments of Nuclear Medicine, Saarland University - Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.; Saarland University, USAAR, Saarbrücken, Germany., Larsen E; Departments of Nuclear Medicine, Saarland University - Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.; Saarland University, USAAR, Saarbrücken, Germany., Khreish F; Departments of Nuclear Medicine, Saarland University - Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.; Department of Nuclear Medicine, Klinikum Fulda gAG, Fulda, Germany., Linxweiler J; Departments of Urology, Saarland University - Medical Center, Homburg, Germany.; Saarland University, USAAR, Saarbrücken, Germany., Marlowe RJ; Spencer-Fontayne Corporation, Jersey City, NJ, USA., Schaefer-Schuler A; Departments of Nuclear Medicine, Saarland University - Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.; Saarland University, USAAR, Saarbrücken, Germany., Maus S; Departments of Nuclear Medicine, Saarland University - Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.; Saarland University, USAAR, Saarbrücken, Germany., Petto S; Departments of Nuclear Medicine, Saarland University - Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.; Saarland University, USAAR, Saarbrücken, Germany., Bartholomä M; Departments of Nuclear Medicine, Saarland University - Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.; Saarland University, USAAR, Saarbrücken, Germany., Ezziddin S; Departments of Nuclear Medicine, Saarland University - Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.; Saarland University, USAAR, Saarbrücken, Germany.
Jazyk: angličtina
Zdroj: Cancer imaging : the official publication of the International Cancer Imaging Society [Cancer Imaging] 2024 Oct 07; Vol. 24 (1), pp. 132. Date of Electronic Publication: 2024 Oct 07.
DOI: 10.1186/s40644-024-00778-5
Abstrakt: Background: Positron emission tomography/computed tomography (PET/CT) using prostate-specific membrane antigen (PSMA)-targeted radiotracers labeled with zirconium-89 ( 89 Zr; half-life ~ 78.41 h) showed promise in localizing biochemical recurrence of prostate cancer (BCR) in pilot studies.
Methods: Retrospective analysis of 38 consecutive men with BCR (median [minimum-maximum] prostate-specific antigen 0.52 (0.12-2.50 ng/mL) undergoing [ 89 Zr]Zr-PSMA-617 PET/CT post-negative [ 68 Ga]Ga-PSMA-11 PET/CT. PET/CT acquisition 1-h, 24-h, and 48-h post-injection of a median (minimum-maximum) [ 89 Zr]Zr-PSMA-617 tracer activity of 123 (84-166) MBq.
Results: [ 89 Zr]Zr-PSMA-617 PET/CT detected altogether 57 lesions: 18 local recurrences, 33 lymph node metastases, 6 bone metastases in 30/38 men with BCR (78%) and prior negative conventional PSMA PET/CT. Lesion uptake significantly increased from 1-h to 24-h and, in a majority of cases, from 24-h to 48-h. Tumor-to-background ratios significantly increased over time, with absolute increases of 100 or more. No side effects were noted. After [ 89 Zr]Zr-PSMA-617 PET/CT-based treatment, prostate-specific antigen concentration decreased in all patients, becoming undetectable in a third of patients.
Limitations: retrospective, single center design; infrequent histopathological and imaging verification.
Conclusion: This large series provides further evidence that [ 89 Zr]Zr-PSMA-617 PET/CT is a beneficial imaging modality to localize early BCR. A remarkable increase in tumor-to-background ratio over time allows localization of tumor unidentified on conventional PSMA PET/CT.
(© 2024. The Author(s).)
Databáze: MEDLINE
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