The attrition, physical and insecticidal durability of two dual active ingredient nets (Interceptor® G2 and Royal Guard®) in Benin, West Africa: results from a durability study embedded in a cluster randomised controlled trial.

Autor: Ngufor C; London School of Hygiene and Tropical Medicine (LSHTM), London, WC1E 7HT, UK. corine.ngufor@lshtm.ac.uk.; Centre de Recherches Entomologiques de Cotonou (CREC), Cotonou, Benin. corine.ngufor@lshtm.ac.uk.; Panafrican Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin. corine.ngufor@lshtm.ac.uk., Fagbohoun J; Centre de Recherches Entomologiques de Cotonou (CREC), Cotonou, Benin.; Panafrican Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin., Fongnikin A; Centre de Recherches Entomologiques de Cotonou (CREC), Cotonou, Benin.; Panafrican Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin., Ahoga J; Centre de Recherches Entomologiques de Cotonou (CREC), Cotonou, Benin.; Panafrican Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin., Syme T; London School of Hygiene and Tropical Medicine (LSHTM), London, WC1E 7HT, UK.; Centre de Recherches Entomologiques de Cotonou (CREC), Cotonou, Benin.; Panafrican Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin., Ahogni I; Centre de Recherches Entomologiques de Cotonou (CREC), Cotonou, Benin.; Panafrican Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin., Accrombessi M; London School of Hygiene and Tropical Medicine (LSHTM), London, WC1E 7HT, UK.; Centre de Recherches Entomologiques de Cotonou (CREC), Cotonou, Benin., Protopopoff N; London School of Hygiene and Tropical Medicine (LSHTM), London, WC1E 7HT, UK., Cook J; London School of Hygiene and Tropical Medicine (LSHTM), London, WC1E 7HT, UK., Dangbenon E; Centre de Recherches Entomologiques de Cotonou (CREC), Cotonou, Benin., Sovi A; London School of Hygiene and Tropical Medicine (LSHTM), London, WC1E 7HT, UK.; Centre de Recherches Entomologiques de Cotonou (CREC), Cotonou, Benin., Baes M; Centre Wallon de Recherches Agronomiques (CRA-W), Gembloux, Belgium., Pigeon O; Centre Wallon de Recherches Agronomiques (CRA-W), Gembloux, Belgium., Todjinou D; Centre de Recherches Entomologiques de Cotonou (CREC), Cotonou, Benin.; Panafrican Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin., Govoetchan R; London School of Hygiene and Tropical Medicine (LSHTM), London, WC1E 7HT, UK.; Centre de Recherches Entomologiques de Cotonou (CREC), Cotonou, Benin.; Panafrican Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin., Padonou GG; Centre de Recherches Entomologiques de Cotonou (CREC), Cotonou, Benin., Akogbeto M; Centre de Recherches Entomologiques de Cotonou (CREC), Cotonou, Benin.
Jazyk: angličtina
Zdroj: Parasites & vectors [Parasit Vectors] 2024 Oct 07; Vol. 17 (1), pp. 420. Date of Electronic Publication: 2024 Oct 07.
DOI: 10.1186/s13071-024-06504-1
Abstrakt: Background: Studies evaluating the attrition, physical and insecticidal durability of dual active ingredient (AI) insecticide-treated nets (ITNs) are essential for making programmatic decisions regarding their deployment. We performed a prospective study embedded in a cluster randomised controlled trial (cRCT) to evaluate the attrition, fabric integrity and insecticidal durability of Interceptor® G2 (alpha-cypermethrin-chlorfenapyr) and Royal Guard® (alpha-cypermethrin-pyriproxyfen), compared to Interceptor® (alpha-cypermethrin) in Benin.
Methods: A total of 2428 study nets in 1093 randomly selected households in five clusters per arm of the cRCT were monitored for ITN attrition and fabric integrity every 6-12 months post-distribution. Householders were further surveyed to investigate non-study net use and their preference for ITN fabric types used in the study nets. A second cohort of 120 nets per ITN type were withdrawn every 12 months and assessed for chemical content and insecticidal activity in laboratory bioassays. Alpha-cypermethrin bioefficacy was investigated using the susceptible Anopheles gambiae Kisumu strain, and chlorfenapyr and pyriproxyfen bioefficacy were investigated using the pyrethroid-resistant Anopheles coluzzii Akron strain. Net pieces were tested in WHO cone bioassays and tunnel tests for alpha-cypermethrin and in tunnel tests for chlorfenapyr; pyriproxyfen activity was assessed in cone bioassays as the reduction in fertility of blood-fed survivors using ovary dissection. Bioefficacy was expressed as the proportion of ITNs passing predetermined WHO criteria, namely knock-down ≥ 95% or 24/72 h mortality ≥ 80% or reduction in fertility ≥ 50%.
Results: Overall ITN survivorship was 52% at 24 months and fell to 15% at 36 months. Median ITN survival time was lower with Royal Guard® relative to Interceptor® [1.6 vs 2.3 years; hazard ratio (HR) 1.49, 95% confidence interval (CI) 1.36-1.66; p < 0.001] and Interceptor® G2 (1.6 vs 2.1 years; HR 1.33, 95% CI 1.20-1.47; p < 0.001). Householders overwhelmingly preferred polyester nets over polyethylene nets (96%), and more Royal Guard® nets were replaced with spare polyester nets from previous campaigns. All Royal Guard® nets passed efficacy criteria for alpha-cypermethrin at all time points (100%) while ITN pass rates after 24 months had fallen to < 40% for pyriproxyfen and chlorfenapyr. The chemical content analysis showed a higher loss rate of the non-pyrethroid insecticides relative to the pyrethroids in each dual ingredient AI ITN; 74% vs 47% for Royal Guard® and 85% vs 63% for Interceptor® G2 at 36 months.
Conclusions: The median ITN survival time for Interceptor® G2 (2.1 years) and Royal Guard® (1.6 years) in Benin is substantially lower than 3 years. Royal Guard® nets were discarded more quickly by householders, partly due to their low preference for polyethylene nets. The insecticidal activity of the non-pyrethroid insecticides in both dual AI ITNs was short-lived compared to alpha-cypermethrin. The results corroborate the findings from the cRCT conducted in Benin.
(© 2024. The Author(s).)
Databáze: MEDLINE
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