Characteristics of gene expression in epicardial adipose tissue and subcutaneous adipose tissue in patients at risk for heart failure undergoing coronary artery bypass grafting.

Autor: Frisk C; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Box 596, Uppsala, S-751 24, Sweden., Ekström M; Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, S-182 88, Sweden.; Department of Cardiology, Danderyd Hospital, Stockholm, S-182 88, Sweden., Eriksson MJ; Department of Clinical Physiology, Karolinska University Hospital, Stockholm, S-171 76, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, S-171 77, Sweden., Corbascio M; Department of Clinical Physiology, Karolinska University Hospital, Stockholm, S-171 76, Sweden.; Department of Thoracic Surgery, Karolinska University Hospital, Stockholm, S-171 76, Sweden., Hage C; Department of Medicine, Karolinska Institutet, Stockholm, S-171 77, Sweden.; Karolinska University Hospital, Heart and Vascular Theme, Stockholm, S-171 76, Sweden., Persson H; Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, S-182 88, Sweden.; Department of Cardiology, Danderyd Hospital, Stockholm, S-182 88, Sweden., Linde C; Department of Medicine, Karolinska Institutet, Stockholm, S-171 77, Sweden.; Karolinska University Hospital, Heart and Vascular Theme, Stockholm, S-171 76, Sweden., Persson B; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Box 596, Uppsala, S-751 24, Sweden. bengt.persson@icm.uu.se.
Jazyk: angličtina
Zdroj: BMC genomics [BMC Genomics] 2024 Oct 07; Vol. 25 (1), pp. 938. Date of Electronic Publication: 2024 Oct 07.
DOI: 10.1186/s12864-024-10851-9
Abstrakt: Background: Epicardial adipose tissue (EAT) surrounds the heart and is hypothesised to play a role in the development of heart failure (HF). In this study, we first investigated the differences in gene expression between epicardial adipose tissue (EAT) and subcutaneous adipose tissue (SAT) in patients undergoing elective coronary artery bypass graft (CABG) surgery (n = 21; 95% male). Secondly, we examined the association between EAT and SAT in patients at risk for HF stage A (n = 12) and in pre-HF patients, who show signs but not symptoms of HF, stage B (n = 9).
Results: The study confirmed a distinct separation between EAT and SAT. In EAT 17 clusters of genes were present, of which several novel gene modules are associated with characteristics of HF. Notably, seven gene modules showed significant correlation to measures of HF, such as end diastolic left ventricular posterior wall thickness, e' mean , deceleration time and BMI. One module was particularly distinct in EAT when compared to SAT, featuring key genes such as FLT4, SEMA3A, and PTX3, which are implicated in angiogenesis, inflammation regulation, and tissue repair, suggesting a unique role in EAT linked to left ventricular dysfunction. Genetic expression was compared in EAT across all pre-HF and normal phenotypes, revealing small genetic changes in the form of 18 differentially expressed genes in ACC/AHA Stage A vs. Stage B.
Conclusions: The roles of subcutaneous and epicardial fat are clearly different. We highlight the gene expression difference in search of potential modifiers of HF progress. The true implications of our findings should be corroborated in other studies since HF ACC/AHA stage B patients are common and carry a considerable risk for progression to symptomatic HF.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: