High-density lipoprotein functionality in cholesterol efflux in early childhood is related to the content ratio of triglyceride to cholesterol.

Autor: Futatsugi A; Department of Medical Genetics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.; Department of Clinical Laboratory, Nagano Children's Hospital, 3100 Toyoshina, Azumino, 399-8288, Japan., Tozuka M; Department of Medical Genetics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan. minoru-tozuka@nkodomo-hsp.jp.; Life Science Research Center, Nagano Children's Hospital, 3100, Toyoshina, Azumino, 399-8288, Japan. minoru-tozuka@nkodomo-hsp.jp., Horiuchi Y; Department of Clinical Laboratory Technology, Faculty of Medical Science, Juntendo University, 6-8-1 Hinode, Urayasu, 279-0013, Japan., Ohkawa R; Department of Clinical Bioanalysis and Molecular Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan., Kosho T; Department of Medical Genetics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.; Center for Medical Genetics, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.; Research Center for Supports to Advanced Science, Shinshu University, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.; BioBank Shinshu, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Oct 07; Vol. 14 (1), pp. 23323. Date of Electronic Publication: 2024 Oct 07.
DOI: 10.1038/s41598-024-74699-5
Abstrakt: Cholesterol efflux capacity (CEC), commonly measured as a useful risk marker of atherosclerotic cardiovascular disease, depends on high-density lipoprotein (HDL) functionality and its concentration. We defined the relative HDL functionality in cholesterol efflux, not influenced by HDL concentration, as the ratio of measured CEC to standardized CEC (stCEC) based on HDL-cholesterol (HDL-C) of each individual using the curve regression equation obtained from the correlation. HDL-C, CEC, and CEC/stCEC levels in the < 28-day-old participants (neonates) were significantly low compared to those of the ≥ 28-day-old participants, indicating that the low CEC levels in the neonates depend on not only lower HDL-C but also lower HDL functionality. The low level of CEC/stCEC was remarkable in neonates born at < 34 weeks of gestation and did not improved to the reference level (1.000) until the infantile period. The relatively low or high CEC/stCEC ratios in neonates and infants were associated with lower or higher HDL-TG and HDL-TG/HDL-C ratio, respectively. However, no apparent effect of HDL-TG and HDL-TG/HDL-C ratio on CEC/stCEC was observed in the ≥ 1-year-old participants, indicating that HDL functionality in cholesterol efflux could be associated with the various HDL particles with various lipid compositions, but not just with HDL-TG and HDL-TG/HDL-C ratio.
(© 2024. The Author(s).)
Databáze: MEDLINE
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