Analysis of zinc and copper levels in very low birth weight infants using human milk additives: phase 1 trial findings.

Autor:	Oliveira RG; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil., Achcar-Feih MC; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil., Nogueira-Pileggi V; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil., Carnevale-Silva A; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil., Carmona F; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil., Aragon DC; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil., Oliveira MM; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil., Fonseca LMM; Department of Maternal-Infantile and Public Health, Nursing School of Ribeirão Preto, University of São Paulo, Brazil., Alves LG; Human Milk Bank, Clinics Hospital, Ribeirão Preto Medical School, University of São Paulo, Brazil., Bomfim VS; Human Milk Bank, Clinics Hospital, Ribeirão Preto Medical School, University of São Paulo, Brazil., Trevilato TMB; Laboratory of Pediatrics, Division of Metals and Rare Diseases, Clinics Hospital, Ribeirão Preto Medical School, University of São Paulo, Brazil., Spido-Dias I; Laboratory of Pediatrics, Division of Metals and Rare Diseases, Clinics Hospital, Ribeirão Preto Medical School, University of São Paulo, Brazil., Ued FV; Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Brazil., Mussi-Pinhata MM; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil., Camelo JS Jr; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil. Electronic address: jscamelo@fmrp.usp.br.
Jazyk:	angličtina
Zdroj:	Jornal de pediatria [J Pediatr (Rio J)] 2024 Oct 05. Date of Electronic Publication: 2024 Oct 05.
DOI:	10.1016/j.jped.2024.08.007
Abstrakt:	Objective: The aim of this study was to assess whether the micronutrients zinc and copper, provided by human milk additives, are sufficient for very low birth weight preterm infants. Method: A phase 1 randomized double-blind controlled trial was conducted with very low birth weight preterm infants. This is a secondary analysis of copper and zinc. Sixty-six newborns were part of the initial sample, with forty participating and reaching the final stage of the study. Inclusion criteria were: gestational age less than 37 weeks, birth weight greater than or equal to 750 g and less than or equal to 1500 g, small or appropriate for gestational age, exclusively receiving human milk at a volume greater than or equal to 100 mL per kilogram per day, and hemodynamically stable. Participants were randomly assigned to two groups: intervention, Lioneo (received human milk with additive based on lyophilized human milk), n = 20, and control, HMCA (received human milk with commercial additive based on cow's milk protein), n = 20, and their serum levels of zinc and copper were measured on the first and twenty-first days. Results: There was a reduction in intragroup zinc serum levels from the first to the twenty-first day of the study (p < 0.01). There was no intergroup difference. No difference was found in serum copper levels. Conclusion: Human milk additives were not sufficient to maintain adequate zinc serum levels in very low birth weight newborns. It was not possible to affirm whether human milk additives were sufficient to maintain adequate serum copper levels in the studied sample. UTN: U1111-1220-0550. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (Copyright © 2024 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.)
Databáze:	MEDLINE
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