A case series of Mediterranean spotted fever and murine typhus with neurological manifestations.

Autor:	Hammami F; Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia., Koubaa M; Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia., Chakroun A; Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia., Rekik K; Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia., Mezghani S; Laboratory of Microbiology, Habib Bourguiba University Hospital, University of Sfax, Tunisia., Hammami A; Laboratory of Microbiology, Habib Bourguiba University Hospital, University of Sfax, Tunisia., Marrakchi C; Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia., Smaoui F; Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia., Jemaa MB; Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia.
Jazyk:	angličtina
Zdroj:	Journal of vector borne diseases [J Vector Borne Dis] 2024 Jul 01; Vol. 61 (3), pp. 489-494. Date of Electronic Publication: 2024 Sep 21.
DOI:	10.4103/0972-9062.383643
Abstrakt:	Background Objectives: Severe cases with neurological manifestations of rickettsiosis have been reported. We aimed to identify the epidemiological, clinical and laboratory features of central nervous system rickettsial infections and to describe the treatment. Methods: We carried out a retrospective study that included all patients hospitalized with rickettsiosis in the infectious diseases department of Hedi Chaker University Hospital in Sfax, Tunisia between 1993 and 2018. Results: We identified 47 patients with central nervous system rickettsial infections among 440 patients with rickettsial infections (10.7%). Skin rash (31.9% vs 87.8%; p<0.001) and eschar (4.2% vs 27.7%; p<0.001) were less frequent among patients with central nervous system rickettsial infections. Complications (6.4% vs 0.5%; p=0.01) and death (4.2% vs 0.3%; p=0.03) were more frequent among patients with central nervous system rickettsial infections. Interpretation Conclusion: Cardinal clinical features and typical laboratory results including thrombocytopenia were less frequent, and prognosis was more severe in patients with central nervous system rickettsial infections. (Copyright © 2024 Copyright: © 2024 Journal of Vector Borne Diseases.)
Databáze:	MEDLINE
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