Lateral Assessment of Mucomimetic Hydrogels to Evaluate Correlation between Microscopic and Macroscopic Properties.

Autor: Faurschou KL; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, M5S 3E5, Canada., Clasky AJ; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, M5S 3E5, Canada., Watchorn J; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, M5S 3E5, Canada.; Acceleration Consortium, University of Toronto, Toronto, Ontario, M5S 3H6, Canada., Tram Su J; Department of Chemical Engineering, McGill University, Montreal, Quebec, H3A 0C5, Canada., Li NT; Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada., McGuigan AP; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, M5S 3E5, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, M5S 3G9, Canada., Gu FX; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, M5S 3E5, Canada.; Acceleration Consortium, University of Toronto, Toronto, Ontario, M5S 3H6, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, M5S 3G9, Canada.
Jazyk: angličtina
Zdroj: Macromolecular bioscience [Macromol Biosci] 2024 Oct 07, pp. e2400146. Date of Electronic Publication: 2024 Oct 07.
DOI: 10.1002/mabi.202400146
Abstrakt: A major limitation in the development of mucosal drug delivery systems is the design of in vitro models that accurately reflect in vivo conditions. Traditionally, models seek to mimic characteristics of physiological mucus, often focusing on property-specific trial metrics such as rheological behavior or diffusion of a nanoparticle of interest. Despite the success of these models, translation from in vitro results to in vivo trials is limited. As a result, several authors have called for work to develop standardized testing methodologies and characterize the influence of model properties on drug delivery performance. To this end, a series of trials is performed on 12 mucomimetic hydrogels reproduced from literature. Experiments show that there is no consistent correlation between barrier performance and rheological or microstructural properties of the tested mucomimetic hydrogels. In addition, the permeability of both mucopenetrating and mucoadhesive nanoparticles is assessed, revealing non-obvious variations in barrier properties such as the relative contributions of electrostatic and hydrophobic interactions in different models. These results demonstrate the limitations of predicting mucomimetic behavior with common characterization techniques and highlight the importance of testing barrier performance with multiple nanoparticle formulations.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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