Exploring environmental and climate features associated with yellow fever across space and time in the Brazilian Atlantic Forest biome.

Autor: Kersul MG; Programa de Pós-Graduação em Ciência Animal da Universidade Estadual de Santa Cruz (UESC), Ilhéus, Bahia, Brazil., Abreu FVS; Laboratório de Comportamento de Insetos, Instituto Federal do Norte de Minas Gerais Campus Salinas, Salinas, Minas Gerais, Brazil., Pinter A; Instituto Pasteur-SES-São Paulo, São Paulo, Brazil., Campos FS; Laboratório de Bioinformática e Biotecnologia, Universidade Federal do Tocantins (UFTO), Palmas, Tocantins, Brazil.; Laboratório de Virologia, Departamento de Microbiologia Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Andrade MS; Setor de Biologia Molecular, Sabin Diagnóstico e Saúde, Brasília, Distrito Federal, Brazil., Teixeira DS; Departamento de Ciências Agrárias e Ambientais (DCAA), UESC, Ilhéus, Bahia, Brazil., Almeida MAB; Organização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, Distrito Federal, Brazil., Roehe PM; Laboratório de Virologia, Departamento de Microbiologia Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Franco AC; Laboratório de Virologia, Departamento de Microbiologia Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Campos AAS; Secretaria Estadual de Saúde do Rio Grande do Sul, Centro Estadual de Vigilância em Saúde, Porto Alegre, Rio Grande do Sul, Brazil., Albuquerque GR; Departamento de Ciências Agrárias e Ambientais (DCAA), UESC, Ilhéus, Bahia, Brazil., Ribeiro BM; Departamento de Biologia Celular, Universidade de Brasília, Brasília, Distrito Federal, Brazil., Sevá ADP; Departamento de Ciências Agrárias e Ambientais (DCAA), UESC, Ilhéus, Bahia, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Oct 07; Vol. 19 (10), pp. e0308560. Date of Electronic Publication: 2024 Oct 07 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0308560
Abstrakt: The Atlantic Forest Biome (AFB) creates an ideal environment for the proliferation of vector mosquitoes, such as Haemagogus and Sabethes species, which transmit the Yellow Fever virus (YFV) to both human and non-human primates (NHP) (particularly Alouatta sp. and Callithrix sp.). From 2016 to 2020, 748 fatal cases of YF in humans and 1,763 in NHPs were reported in this biome, following several years free from the disease. This underscores the imminent risk posed by the YFV. In this study, we examined the spatiotemporal distribution patterns of YF cases in both NHPs and humans across the entire AFB during the outbreak period, using a generalized linear mixed regression model (GLMM) at the municipal level. Our analysis examined factors associated with the spread of YFV, including environmental characteristics, climate conditions, human vaccination coverage, and the presence of two additional YFV-affected NHP species. The occurrence of epizootics has been directly associated with natural forest formations and the presence of species within the Callithrix genus. Additionally, epizootics have been shown to be directly associated with human prevalence. Furthermore, human prevalence showed an inverse correlation with urban areas, temporary croplands, and savannah and grassland areas. Further analyses using Moran's Index to incorporate the neighborhoods of municipalities with cases in each studied host revealed additional variables, such as altitude, which showed a positive correlation. Additionally, the occurrence of the disease in both hosts exhibited a spatio-temporal distribution pattern. To effectively mitigate the spread of the virus, it is necessary to proactively expand vaccination coverage, refine NHP surveillance strategies, and enhance entomological surveillance in both natural and modified environments.
Competing Interests: We declare that we have no known competing personal relationships or financial interests that could appear to have influenced the work reported in this paper.
(Copyright: © 2024 Kersul et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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