Absolute coronary flow and microvascular resistance before and after transcatheter aortic valve implantation.
| Autor: | Gallinoro E; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium.; Division of University Cardiology, IRCCS Galeazzi - Sant'Ambrogio Hospital, Milan, Italy., Paolisso P; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium.; Division of University Cardiology, IRCCS Galeazzi - Sant'Ambrogio Hospital, Milan, Italy., Bertolone DT; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium., Esposito G; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium.; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy., Belmonte M; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium.; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy., Leone A; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium.; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy., Viscusi MM; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium.; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy., Shumkova M; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium., De Colle C; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium., Degrieck I; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium., Casselman F; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium., Penicka M; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium., Collet C; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium., Sonck J; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium., Wyffels E; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium., Bartunek J; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium., De Bruyne B; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium.; Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland., Vanderheyden M; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium., Barbato E; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium.; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology [EuroIntervention] 2024 Oct 07; Vol. 20 (19), pp. e1248-e1528. Date of Electronic Publication: 2024 Oct 07. |
| DOI: | 10.4244/EIJ-D-24-00075 |
| Abstrakt: | Background: Severe aortic stenosis (AS) is associated with left ventricular (LV) remodelling, likely causing alterations in coronary blood flow and microvascular resistance. Aims: We aimed to evaluate changes in absolute coronary flow and microvascular resistance in patients with AS undergoing transcatheter aortic valve implantation (TAVI). Methods: Consecutive patients with AS undergoing TAVI with non-obstructive coronary artery disease in the left anterior descending artery (LAD) were included. Absolute coronary flow (Q) and microvascular resistance (R Results: In 51 patients, Q and R were measured at rest and during hyperaemia before and after TAVI; in 20 (39%) patients, measurements were also obtained 6 months after TAVI. No changes occurred in resting and hyperaemic flow and resistance before and after TAVI nor after 6 months. However, at 6-month follow-up, a notable reverse LV remodelling resulted in a significant increase in hyperaemic perfusion (Q Conclusions: Immediately after TAVI, no changes occurred in absolute coronary flow or coronary flow reserve. Over time, the remodelling of the left ventricle is associated with increased hyperaemic perfusion. |
| Databáze: | MEDLINE |
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