New Processes for Ionizing Nonvolatile Compounds in Mass Spectrometry: The Road of Discovery to Current State-of-the-Art.

Autor:	Trimpin S; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.; MSTM, LLC, Newark, Delaware 19711, United States., Yenchick FS; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Lee C; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Hoang K; MSTM, LLC, Newark, Delaware 19711, United States.; Saint Joseph's University, Philadelphia, Pennsylvania 19104, United States., Pophristic M; MSTM, LLC, Newark, Delaware 19711, United States.; Saint Joseph's University, Philadelphia, Pennsylvania 19104, United States., Karki S; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.; MSTM, LLC, Newark, Delaware 19711, United States., Marshall DD; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.; MSTM, LLC, Newark, Delaware 19711, United States., Lu IC; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.; Department of Chemistry, National Chung Hsing University, Taichung, 402, Taiwan., Lutomski CA; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., El-Baba TJ; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Wang B; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Pagnotti VS; Saint Joseph's University, Philadelphia, Pennsylvania 19104, United States., Meher AK; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.; MSTM, LLC, Newark, Delaware 19711, United States., Chakrabarty S; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.; MSTM, LLC, Newark, Delaware 19711, United States., Imperial LF; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Madarshahian S; Saint Joseph's University, Philadelphia, Pennsylvania 19104, United States., Richards AL; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Lietz CB; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Moreno-Pedraza A; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Leach SM; Department of Forensic Sciences (DFS), Washington, D.C. 20024, United States., Gibson SC; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Elia EA; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Thawoos SM; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Woodall DW; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Jarois DR; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Davis ETJ; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Liao G; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Muthunayake NS; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Redding MJ; Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, United States., Reynolds CA; Wayne State University School of Medicine, Detroit, Michigan 48201, United States., Anthony TM; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Vithanarachchi SM; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., DeMent P; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Adewale AO; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Yan L; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Wager-Miller J; Gill Center for Biomolecular Science and Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405, United States., Ahn YH; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Sanderson TH; Wayne State University School of Medicine, Detroit, Michigan 48201, United States., Przyklenk K; Wayne State University School of Medicine, Detroit, Michigan 48201, United States., Greenberg ML; Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, United States., Suits AG; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Allen MJ; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Narayan SB; Detroit Medical Center: Detroit Hospital (DMC), Detroit, Michigan 48201, United States., Caruso JA; Institute of Environmental Health Sciences, Wayne State University, Detroit Michigan 48202, United States., Stemmer PM; Institute of Environmental Health Sciences, Wayne State University, Detroit Michigan 48202, United States., Nguyen HM; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Weidner SM; Federal Institute for Materials Research and Testing (BAM), Berlin 12489, Germany., Rackers KJ; Automation Techniques, Inc, Greensboro, North Carolina 27407, United States., Djuric A; College of Engineering, Wayne State University, Detroit, Michigan 48202, United States., Shulaev V; Department of Biological Sciences, BioDiscovery Institute, University of North Texas, Denton, Texas 76210, United States., Hendrickson TL; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Chow CS; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Pflum MKH; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Grayson SM; Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, United States., Lobodin VV; BASF Corporation, Wyandotte, Michigan 48192, United States., Guo Z; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States., Ni CK; Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 10617, Taiwan., Walker JM; Gill Center for Biomolecular Science and Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405, United States., Mackie K; Gill Center for Biomolecular Science and Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405, United States., Inutan ED; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.; MSTM, LLC, Newark, Delaware 19711, United States.; Mindanao State University Iligan Institute of Technology, Iligan City 9200, Philippines., McEwen CN; MSTM, LLC, Newark, Delaware 19711, United States.; Saint Joseph's University, Philadelphia, Pennsylvania 19104, United States.
Jazyk:	angličtina
Zdroj:	Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2024 Oct 07. Date of Electronic Publication: 2024 Oct 07.
DOI:	10.1021/jasms.3c00122
Abstrakt:	This Perspective covers discovery and mechanistic aspects as well as initial applications of novel ionization processes for use in mass spectrometry that guided us in a series of subsequent discoveries, instrument developments, and commercialization. Vacuum matrix-assisted ionization on an intermediate pressure matrix-assisted laser desorption/ionization source without the use of a laser, high voltages, or any other added energy was simply unbelievable, at first. Individually and as a whole, the various discoveries and inventions started to paint, inter alia , an exciting new picture and outlook in mass spectrometry from which key developments grew that were at the time unimaginable, and continue to surprise us in its simplistic preeminence. We, and others, have demonstrated exceptional analytical utility. Our current research is focused on how best to understand, improve, and use these novel ionization processes through dedicated platforms and source developments. These ionization processes convert volatile and nonvolatile compounds from solid or liquid matrixes into gas-phase ions for analysis by mass spectrometry using, e.g. , mass-selected fragmentation and ion mobility spectrometry to provide accurate, and sometimes improved, mass and drift time resolution. The combination of research and discoveries demonstrated multiple advantages of the new ionization processes and established the basis of the successes that lead to the Biemann Medal and this Perspective. How the new ionization processes relate to traditional ionization is also presented, as well as how these technologies can be utilized in tandem through instrument modification and implementation to increase coverage of complex materials through complementary strengths.
Databáze:	MEDLINE
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