RNA modifications in cancer immune therapy: regulators of immune cells and immune checkpoints.

Autor:	Qin X; Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China.; Renmin Hospital of Wuhan Economic and Technological Development Zone (Hannan), Wuhan, China.; Wuhan University Heavy Ion Medicine Center, Wuhan, China., Liu H; Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China., Zhang Q; Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, China., Che Y; Renmin Hospital of Wuhan Economic and Technological Development Zone (Hannan), Wuhan, China.; Wuhan University Heavy Ion Medicine Center, Wuhan, China., Lei T; Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China.; Renmin Hospital of Wuhan Economic and Technological Development Zone (Hannan), Wuhan, China.; Wuhan University Heavy Ion Medicine Center, Wuhan, China., Tang F; Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China., Hu Q; Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China.; Renmin Hospital of Wuhan Economic and Technological Development Zone (Hannan), Wuhan, China.; Wuhan University Heavy Ion Medicine Center, Wuhan, China.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Sep 20; Vol. 15, pp. 1463847. Date of Electronic Publication: 2024 Sep 20 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1463847
Abstrakt:	RNA modifications are epigenetic changes that alter the structure and function of RNA molecules, playing a crucial role in the onset, progression, and treatment of cancer. Immune checkpoint inhibitor (ICI) therapies, particularly PD-1 blockade and anti-CTLA-4 treatments, have changed the treatment landscape of virous cancers, showing great potential in the treatment of different cancer patients, but sensitivity to these therapies is limited to certain individuals. This review offers a comprehensive survey of the functions and therapeutic implications of the four principal RNA modifications, particularly highlighting the significance of m6A in the realms of immune cells in tumor and immunotherapy. This review starts by providing a foundational summary of the roles RNA modifications assume within the immune cell community, focusing on T cells, NK cells, macrophages, and dendritic cells. We then discuss how RNA modifications influence the intricate regulatory mechanisms governing immune checkpoint expression, modulation of ICI efficacy, and prediction of ICI treatment outcomes, and review drug therapies targeting genes regulated by RNA modifications. Finally, we explore the role of RNA modifications in gene editing, cancer vaccines, and adoptive T cell therapies, offering valuable insights into the use of RNA modifications in cancer immunotherapy. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Qin, Liu, Zhang, Che, Lei, Tang and Hu.)
Databáze:	MEDLINE
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