Aerosolic Application of Phages Against S. infantis on Plates and Chicken Skin.

Autor: Winkelmayer L; Austrian Agency for Health and Food Safety, Vienna, Austria., Rathammer K; Austrian Agency for Health and Food Safety, Vienna, Austria., Richter S; Austrian Agency for Health and Food Safety, Vienna, Austria., Requat T; Austrian Agency for Health and Food Safety, Vienna, Austria., Matt M; Austrian Agency for Health and Food Safety, Vienna, Austria., Ljuhar D; Braincon GmbH & Co KG, Vienna, Austria., Jäger P; Braincon GmbH & Co KG, Vienna, Austria., Kernmauner F; Braincon GmbH & Co KG, Vienna, Austria., Naemi S; Braincon GmbH & Co KG, Vienna, Austria., Mansfeld MD; ILV Kaernten, Veterinaermedizinische Untersuchungen, Carinthia, Austria., Duscher GG; Austrian Agency for Health and Food Safety, Vienna, Austria.
Jazyk: angličtina
Zdroj: PHAGE (New Rochelle, N.Y.) [Phage (New Rochelle)] 2024 Sep 16; Vol. 5 (3), pp. 126-129. Date of Electronic Publication: 2024 Sep 16 (Print Publication: 2024).
DOI: 10.1089/phage.2023.0037
Abstrakt: Phages are known as a promising method to combat antimicrobial resistance (AMR) in the human and veterinary sector. Use of phage aerosols enormously increases the application field, although the impact on the infectivity of phages during nebulization needs to be evaluated. In this study S. infantis was treated on plates and chicken skin with nebulized phage particles of the Myoviridae type, identified by transmission electron microscopy, using a commercial nebulizer primarily used for H 2 O 2 disinfection. The reduction of bacterial number by aerosol applied phage particles was evaluated. It could clearly be shown that the phage particles were able to infect Salmonella after being nebulized using ultrasound technology. Further studies on other types of phages as well as other conditions must be performed to standardize the aerosolic application of phages.
(Copyright 2024, Mary Ann Liebert, Inc., publishers.)
Databáze: MEDLINE
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