The effects of photochemical aging and interactions with secondary organic aerosols on cellular toxicity of combustion particles.

Autor: Attah R; Department of Chemical Engineering, University of Utah, Salt Lake City, UT, United States of America., Kaur K; Department of Chemical Engineering, University of Utah, Salt Lake City, UT, United States of America., Reilly CA; Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, United States., Deering-Rice CE; Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, United States., Kelly KE; Department of Chemical Engineering, University of Utah, Salt Lake City, UT, United States of America.
Jazyk: angličtina
Zdroj: Journal of aerosol science [J Aerosol Sci] 2025 Jan; Vol. 183. Date of Electronic Publication: 2024 Sep 24.
DOI: 10.1016/j.jaerosci.2024.106473
Abstrakt: Fine particulate matter (PM 2.5 ) is associated with numerous adverse health effects, including pulmonary and cardiovascular diseases and premature death. Significant contributors to ambient PM 2.5 include combustion particles and secondary organic aerosols (SOA). Combustion particles enter the atmosphere and undergo an aging process that changes their shape and composition, but there is limited study on the health effects of combustion particle aging and interactions with SOA. This study aimed to understand how biological responses to combustion particles would be affected by atmospheric aging and interaction with anthropogenic SOA. Fresh combustion particles underwent photochemical aging in a potential aerosol mass (PAM) oxidation flow reactor and interacted with SOA produced by the oxidation of toluene vapor in the PAM reactor. Photochemical aging and SOA interactions lead to significant changes in the PAH content and oxidative potential of the particle. Photochemical aging and SOA interactions also affected the biological responses, such as the inflammatory response and CYP1A1 induction of the particles in monoculture and coculture cells. These findings highlight the significance of photochemical aging and SOA interactions on the composition and cellular responses of combustion particles.
Competing Interests: Kerry Kelly, Christopher A. Reilly reports financial support was provided by National Institutes of Health. Dr. Kelly has a financial interest in TELLUS Networked Sensor Solutions, Inc., which commercializes air quality monitoring devices” No TELLUS technology was used as part of this study If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Dr. Kelly has a financial interest in TELLUS Networked Sensor Solutions, Inc., which commercializes air quality monitoring devices” No TELLUS technology was used as part of this study.
Databáze: MEDLINE
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