Hereditary Angioedema in Pregnancy Complicated by Upper Extremity Deep Venous Thrombosis: A Case Report.
| Autor: | Newton DH; Medical Student, Alabama College of Osteopathic Medicine, Dothan, USA., Betit AL; Medical Student, Alabama College of Osteopathic Medicine, Dothan, USA., Patel RB; Medical Student, Alabama College of Osteopathic Medicine, Dothan, USA., DiValentin L; Internal Medicine, Regional Medical Center, Anniston, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Sep 04; Vol. 16 (9), pp. e68641. Date of Electronic Publication: 2024 Sep 04 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.68641 |
| Abstrakt: | Hereditary angioedema (HAE) is a rare disorder that causes episodes of angioedema due to a mutation in the C1 esterase inhibitor gene (C1-INH). Complications of HAE include intestinal obstruction, asphyxiation, and venous thromboembolism (VTE). In this case, we report a 34-year-old G4P2011 female with HAE at 24 weeks gestation presenting with acute right upper extremity pain and swelling following a peripherally inserted central catheter (PICC) line for HAE treatment infusion, revealing a right upper extremity VTE. Early treatment with Lovenox, PICC line removal, and continuation of HAE therapy via peripheral IV infusion resolved and prevented further angioedema and subsequent VTEs during this patient's pregnancy. This case serves as an example of effective management of HAE complications during pregnancy and supports peripheral IV line usage over PICC lines for medication infusions in pregnant patients with HAE. The overall purpose of this case report is to improve safety outcomes for pregnant patients with HAE by mitigating the risks of PICC line usage and to highlight the significance of VTE inclusion within the differential diagnosis in this population. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Newton et al.) |
| Databáze: | MEDLINE |
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