First imported Cases of MPXV Clade Ib in Goma, Democratic Republic of the Congo: Implications for Global Surveillance and Transmission Dynamics.

Autor:	Mukadi-Bamuleka D; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo., Kinganda-Lusamaki E; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.; TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier, Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), Montpellier, France., Mulopo-Mukanya N; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo., Amuri-Aziza A; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., O'Toole Á; Institute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK., Modadra-Madakpa B; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo., Ndongala GM; Provincial Health Division, North Kivu, Democratic Republic of the Congo., Vakaniaki EH; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., Merritt S; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, California, USA., Kacita C; Hemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa, Democratic Republic of the Congo., Maboko GL; Provincial Health Division, North Kivu, Democratic Republic of the Congo., Makangara-Cigolo JC; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., Ngimba M; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo., Lokilo E; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., Pukuta-Simbu E; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., Luakanda G; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., Bodisa-Matamu T; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo., Kalimuli ZP; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo., Akil-Bandali P; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., Kavira S; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., Jansen D; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Kamaliro AK; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., Muhindo-Milonde E; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., Mufungizi J; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo., Hamisi YB; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo., Kavunga H; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo., Tshiani O; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., Nundu SS; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., Liesenborghs L; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Hoff NA; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, California, USA., Nachega J; Department of Epidemiology, Infectious Diseases and Microbiology, University of Pittsburgh, School of Public Health, Pittsburgh, Pennsylvania, USA., Shongo R; Hemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa, Democratic Republic of the Congo., Ayouba A; TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier, Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), Montpellier, France., Pilarowski G; Chan Zuckerberg Biohub, San Francisco, California, USA., Mangolopa AK; World Health Organization, Geneva, Switzerland., Ebondo AK; World Health Organization, Geneva, Switzerland., Low N; University of Bern, Bern, Switzerland., Shaw SY; Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Wilkinson S; University of Birmingham, Birmingham, UK., Tessema SK; Africa Centres for Disease Control and Prevention, Addis Ababa, Ethiopia., Subissi L; World Health Organization, Geneva, Switzerland., Delaporte E; TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier, Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), Montpellier, France., Vercauteren K; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Wawina-Bokalanga T; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Rimoin AW; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, California, USA., Peeters M; TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier, Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), Montpellier, France., Loman N; University of Birmingham, Birmingham, UK., Rambaut A; TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier, Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), Montpellier, France., Muyembe-Tamfum JJ; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., Hensley LE; US Department of Agriculture, Agricultural Research Service, Manhattan, Kansas, USA., Kindrachuk J; Department of Medical Microbiology & Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Internal Medicine, University of Manitoba, Canada., Mbala-Kingebeni P; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo., Ahuka-Mundeke S; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.; Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 Sep 16. Date of Electronic Publication: 2024 Sep 16.
DOI:	10.1101/2024.09.12.24313188
Abstrakt:	The ongoing national mpox outbreak in the Democratic Republic of the Congo has resulted in more >30,000 suspected cases in the country from January 2023 to August 2024. While these historic case totals have been driven by primarily by zoonosis, the emergence of Clade Ib monkeypox virus (MPXV), which is connected to more sustained human-to-human transmission, has been associated with increasing public health impacts in eastern DRC. First identified in South Kivu province, Clade Ib MPXV has been identified in multiple non-endemic East African countries for the first time. In DRC, there have been concerns over broader Clade Ib expansion in the country that could further complicate containment and mitigation responses. Here, we report the first introductions of Clade Ib into North Kivu province, including within internal displacement camps, with suspected close contact transmission that includes non-intimate contacts and children. These findings demonstrate that mpox case investigations and community messaging campaigns should include considerations for non-sexual contact-mediated transmission of Clade Ib that includes children <15 years. Competing Interests: COMPETING INTERESTS None of the other authors declare competing interests.
Databáze:	MEDLINE
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